FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316664088> ?p ?o ?g. }

• W4316664088 endingPage "225" @default.
• W4316664088 startingPage "225" @default.
• W4316664088 abstract "Leishmaniasis is a neglected tropical disease, affecting more than 350 million people globally. However, there is currently no vaccine available against human leishmaniasis, and current treatment is hampered by high cost, side-effects, and painful administration routes. It has become a United Nations goal to end leishmaniasis epidemics by 2030, and multitarget drug strategy emerges as a promising alternative. Among the multitarget compounds, flavonoids are a renowned class of natural products, and a structurally diverse library can be prepared through organic synthesis, which can be tested for biological effectiveness. In this study, we synthesised 17 flavonoid analogues using a scalable, easy-to-reproduce, and inexpensive method. All synthesised compounds presented an impressive inhibition capacity against rCPB2.8, rCPB3, and rH84Y enzymes, which are highly expressed in the amastigote stage, the target form of the parasite. Compounds 3c, f12a, and f12b were found to be effective against all isoforms. Furthermore, their intermolecular interactions were also investigated through a molecular modelling study. These compounds were highly potent against the parasite and demonstrated low cytotoxic action against mammalian cells. These results are pioneering, representing an advance in the investigation of the mechanisms behind the antileishmanial action of flavonoid derivatives. Moreover, compounds have been shown to be promising leads for the design of other cysteine protease inhibitors for the treatment of leishmaniasis diseases." @default.
• W4316664088 created "2023-01-17" @default.
• W4316664088 creator A5018759681 @default.
• W4316664088 creator A5021881013 @default.
• W4316664088 creator A5030202488 @default.
• W4316664088 creator A5031894875 @default.
• W4316664088 creator A5035891175 @default.
• W4316664088 creator A5036663494 @default.
• W4316664088 creator A5040885471 @default.
• W4316664088 creator A5048507469 @default.
• W4316664088 creator A5053949967 @default.
• W4316664088 creator A5057544519 @default.
• W4316664088 creator A5062902286 @default.
• W4316664088 creator A5066093847 @default.
• W4316664088 creator A5091450977 @default.
• W4316664088 date "2023-01-16" @default.
• W4316664088 modified "2023-10-05" @default.
• W4316664088 title "Flavonoid Derivatives as New Potent Inhibitors of Cysteine Proteases: An Important Step toward the Design of New Compounds for the Treatment of Leishmaniasis" @default.
• W4316664088 cites W1501405435 @default.
• W4316664088 cites W1978179295 @default.
• W4316664088 cites W1999794120 @default.
• W4316664088 cites W2005495585 @default.
• W4316664088 cites W2019619543 @default.
• W4316664088 cites W2028270779 @default.
• W4316664088 cites W2041791898 @default.
• W4316664088 cites W2049743131 @default.
• W4316664088 cites W2066102229 @default.
• W4316664088 cites W2070753604 @default.
• W4316664088 cites W2074752318 @default.
• W4316664088 cites W2074755706 @default.
• W4316664088 cites W2094251054 @default.
• W4316664088 cites W2097984793 @default.
• W4316664088 cites W2109689528 @default.
• W4316664088 cites W2114282783 @default.
• W4316664088 cites W2115472563 @default.
• W4316664088 cites W2121896707 @default.
• W4316664088 cites W2123874690 @default.
• W4316664088 cites W2132629607 @default.
• W4316664088 cites W2135732933 @default.
• W4316664088 cites W2143278515 @default.
• W4316664088 cites W2143287044 @default.
• W4316664088 cites W2149238326 @default.
• W4316664088 cites W2155208683 @default.
• W4316664088 cites W2158935187 @default.
• W4316664088 cites W2171268876 @default.
• W4316664088 cites W2256484307 @default.
• W4316664088 cites W2322406384 @default.
• W4316664088 cites W2593436234 @default.
• W4316664088 cites W2604824156 @default.
• W4316664088 cites W2613749397 @default.
• W4316664088 cites W2729684734 @default.
• W4316664088 cites W2736732523 @default.
• W4316664088 cites W2783897572 @default.
• W4316664088 cites W2804822363 @default.
• W4316664088 cites W2885053482 @default.
• W4316664088 cites W2887795636 @default.
• W4316664088 cites W2888130386 @default.
• W4316664088 cites W2898199207 @default.
• W4316664088 cites W2903073052 @default.
• W4316664088 cites W2904187231 @default.
• W4316664088 cites W2912261390 @default.
• W4316664088 cites W2923099100 @default.
• W4316664088 cites W2993331616 @default.
• W4316664088 cites W3015950503 @default.
• W4316664088 cites W3029979937 @default.
• W4316664088 cites W3040242123 @default.
• W4316664088 cites W3084944284 @default.
• W4316664088 cites W3088783364 @default.
• W4316664088 cites W3124714605 @default.
• W4316664088 cites W3125784366 @default.
• W4316664088 cites W3129344388 @default.
• W4316664088 cites W3133717781 @default.
• W4316664088 cites W3139523035 @default.
• W4316664088 cites W3172938498 @default.
• W4316664088 cites W3176159716 @default.
• W4316664088 cites W3198669059 @default.
• W4316664088 cites W3206057363 @default.
• W4316664088 cites W3216183523 @default.
• W4316664088 cites W4200111632 @default.
• W4316664088 cites W4205763895 @default.
• W4316664088 cites W4220897552 @default.
• W4316664088 cites W4248107770 @default.
• W4316664088 cites W4255604777 @default.
• W4316664088 cites W941846375 @default.
• W4316664088 doi "https://doi.org/10.3390/microorganisms11010225" @default.
• W4316664088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36677517" @default.
• W4316664088 hasPublicationYear "2023" @default.
• W4316664088 type Work @default.
• W4316664088 citedByCount "1" @default.
• W4316664088 crossrefType "journal-article" @default.
• W4316664088 hasAuthorship W4316664088A5018759681 @default.
• W4316664088 hasAuthorship W4316664088A5021881013 @default.
• W4316664088 hasAuthorship W4316664088A5030202488 @default.
• W4316664088 hasAuthorship W4316664088A5031894875 @default.
• W4316664088 hasAuthorship W4316664088A5035891175 @default.
• W4316664088 hasAuthorship W4316664088A5036663494 @default.
• W4316664088 hasAuthorship W4316664088A5040885471 @default.
• W4316664088 hasAuthorship W4316664088A5048507469 @default.

• next