FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316670129> ?p ?o ?g. }

• W4316670129 abstract "Metastases are the primary cause of death among cancer patients and efficacious new treatments are sorely needed. Targeted alpha-emitting radiopharmaceuticals that are highly cytotoxic may fulfill this critical need. The focus of this paper is to describe and explore a novel technology that may improve the therapeutic effect of targeted alpha therapy by combining two radionuclides from the same decay chain in the same solution. We hypothesize that the dual targeting solution containing bone-seeking 224Ra and cell-directed complexes of progeny 212Pb is a promising approach to treat metastatic cancers with bone and soft tissue lesions as well as skeletal metastases of mixed lytic/osteoblastic nature. A novel liquid 224Ra/212Pb-generator for rapid preparation of a dual targeting solution is described. Cancer cell targeting monoclonal antibodies, their fragments, synthetic proteins or peptides can all be radiolabeled with 212Pb in the 224Ra-solution in transient equilibrium with daughter nuclides. Thus, 224Ra targets stromal elements in sclerotic bone metastases and 212Pb-chelated-conjugate targets tumor cells of metastatic prostate cancer or osteosarcoma. The dual targeting solution may also be explored to treat metastatic breast cancer or multiple myeloma after manipulation of bone metastases to a more osteoblastic phenotype by the use of bisphosphonates, denosumab, bortezomib or hormone therapy prior to treatment. This may improve targeting of bone-seeking 224Ra and render an augmented radiation dose deposited within metastases. Our preliminary preclinical studies provide conceptual evidence that the dual 224Ra-solution with bone or tumor-targeted delivery of 212Pb has potential to inhibit cancer metastases without significant toxicity. In some settings, the use of a booster dose of purified 212Pb-conjugate alone could be required to elevate the effect of this tumor cell directed component, if needed, e.g., in a fractionated treatment regimen, where the dual targeting solution will act as maintenance treatment." @default.
• W4316670129 created "2023-01-17" @default.
• W4316670129 creator A5005283403 @default.
• W4316670129 creator A5023483696 @default.
• W4316670129 creator A5035939033 @default.
• W4316670129 creator A5055369749 @default.
• W4316670129 creator A5081944301 @default.
• W4316670129 date "2023-01-17" @default.
• W4316670129 modified "2023-09-26" @default.
• W4316670129 title "Dual targeting with 224Ra/212Pb-conjugates for targeted alpha therapy of disseminated cancers: A conceptual approach" @default.
• W4316670129 cites W1621696727 @default.
• W4316670129 cites W164142635 @default.
• W4316670129 cites W1781592116 @default.
• W4316670129 cites W1914046922 @default.
• W4316670129 cites W1966016287 @default.
• W4316670129 cites W1972714302 @default.
• W4316670129 cites W1973328408 @default.
• W4316670129 cites W1979624352 @default.
• W4316670129 cites W1986275950 @default.
• W4316670129 cites W1988641059 @default.
• W4316670129 cites W2016200341 @default.
• W4316670129 cites W2019601924 @default.
• W4316670129 cites W2032914997 @default.
• W4316670129 cites W2058481745 @default.
• W4316670129 cites W2061879199 @default.
• W4316670129 cites W2081177431 @default.
• W4316670129 cites W2086636804 @default.
• W4316670129 cites W2088799733 @default.
• W4316670129 cites W2089609312 @default.
• W4316670129 cites W2100642978 @default.
• W4316670129 cites W2102774138 @default.
• W4316670129 cites W2107712643 @default.
• W4316670129 cites W2110583473 @default.
• W4316670129 cites W2122878067 @default.
• W4316670129 cites W2125047406 @default.
• W4316670129 cites W2125544080 @default.
• W4316670129 cites W2141454098 @default.
• W4316670129 cites W2147376175 @default.
• W4316670129 cites W2166395132 @default.
• W4316670129 cites W2174052209 @default.
• W4316670129 cites W2224941815 @default.
• W4316670129 cites W2316597678 @default.
• W4316670129 cites W2319587259 @default.
• W4316670129 cites W2467018059 @default.
• W4316670129 cites W2527471932 @default.
• W4316670129 cites W2545169478 @default.
• W4316670129 cites W2608027638 @default.
• W4316670129 cites W2612478849 @default.
• W4316670129 cites W2783992930 @default.
• W4316670129 cites W2800714919 @default.
• W4316670129 cites W2801430183 @default.
• W4316670129 cites W2808551116 @default.
• W4316670129 cites W28086221 @default.
• W4316670129 cites W2885361645 @default.
• W4316670129 cites W2948315431 @default.
• W4316670129 cites W2967213355 @default.
• W4316670129 cites W2969063465 @default.
• W4316670129 cites W2979714068 @default.
• W4316670129 cites W2988259296 @default.
• W4316670129 cites W2990351859 @default.
• W4316670129 cites W2990820942 @default.
• W4316670129 cites W2991510024 @default.
• W4316670129 cites W2999876022 @default.
• W4316670129 cites W3002452194 @default.
• W4316670129 cites W3007334567 @default.
• W4316670129 cites W3009386304 @default.
• W4316670129 cites W3015002607 @default.
• W4316670129 cites W3016202049 @default.
• W4316670129 cites W3023450719 @default.
• W4316670129 cites W3023489917 @default.
• W4316670129 cites W3048934302 @default.
• W4316670129 cites W3089551743 @default.
• W4316670129 cites W3127460289 @default.
• W4316670129 cites W3127869214 @default.
• W4316670129 cites W3132107456 @default.
• W4316670129 cites W3133384495 @default.
• W4316670129 cites W3133568034 @default.
• W4316670129 cites W3151078015 @default.
• W4316670129 cites W3158522163 @default.
• W4316670129 cites W3159214145 @default.
• W4316670129 cites W3160647716 @default.
• W4316670129 cites W3160757120 @default.
• W4316670129 cites W3164968678 @default.
• W4316670129 cites W3171439056 @default.
• W4316670129 cites W3176208875 @default.
• W4316670129 cites W3180671804 @default.
• W4316670129 cites W3186750455 @default.
• W4316670129 cites W3194792247 @default.
• W4316670129 cites W3204460422 @default.
• W4316670129 cites W3205335628 @default.
• W4316670129 cites W3210205595 @default.
• W4316670129 cites W3210555953 @default.
• W4316670129 cites W4200608463 @default.
• W4316670129 cites W4205533766 @default.
• W4316670129 cites W4206449342 @default.
• W4316670129 cites W4206899631 @default.
• W4316670129 cites W4225792535 @default.
• W4316670129 cites W4226290853 @default.
• W4316670129 cites W4250957936 @default.
• W4316670129 cites W4280601090 @default.

• next