FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316672029> ?p ?o ?g. }

• W4316672029 abstract "The contribution of bone-marrow derived cells (BMCs) to a newly formed beta-cell population in adults is controversial. Previous studies have only used models of bone marrow transplantation from sex-mismatched donors (or other models of genetic labeling) into recipient animals that had undergone irradiation. This approach suffers from the significant shortcoming of the off-target effects of irradiation. Partial pancreatic duct ligation (PDL) is a mouse model of acute pancreatitis with a modest increase in beta-cell number. However, the possibility that recruited BMCs in the inflamed pancreas may convert into beta-cells has not been examined. Here, we used an irradiation-free model to track the fate of the BMCs from the donor mice. A ROSA-mTmG red fluorescent mouse was surgically joined to an INS1Cre knock-in mouse by parabiosis to establish a mixed circulation. PDL was then performed in the INS1Cre mice 2 weeks after parabiosis, which was one week after establishment of the stable blood chimera. The contribution of red cells from ROSA-mTmG mice to beta-cells in INS1Cre mouse was evaluated based on red fluorescence, while cell fusion was evaluated by the presence of green fluorescence in beta-cells. We did not detect any red or green insulin+ cells in the INS1Cre mice, suggesting that there was no contribution of BMCs to the newly formed beta-cells, either by direct differentiation, or by cell fusion. Thus, the contribution of BMCs to beta-cells in the inflamed pancreas should be minimal, if any." @default.
• W4316672029 created "2023-01-17" @default.
• W4316672029 creator A5002950176 @default.
• W4316672029 creator A5007547858 @default.
• W4316672029 creator A5010078682 @default.
• W4316672029 creator A5020003523 @default.
• W4316672029 creator A5034836281 @default.
• W4316672029 creator A5036766747 @default.
• W4316672029 creator A5040415029 @default.
• W4316672029 creator A5044556352 @default.
• W4316672029 creator A5048766021 @default.
• W4316672029 creator A5059306287 @default.
• W4316672029 creator A5059374757 @default.
• W4316672029 creator A5078653342 @default.
• W4316672029 date "2023-01-17" @default.
• W4316672029 modified "2023-10-16" @default.
• W4316672029 title "Bone-marrow derived cells do not contribute to new beta-cells in the inflamed pancreas" @default.
• W4316672029 cites W136575263 @default.
• W4316672029 cites W1758705766 @default.
• W4316672029 cites W1973605050 @default.
• W4316672029 cites W1976221714 @default.
• W4316672029 cites W1977148504 @default.
• W4316672029 cites W1993902386 @default.
• W4316672029 cites W1995812738 @default.
• W4316672029 cites W2000574178 @default.
• W4316672029 cites W2028679519 @default.
• W4316672029 cites W2033209163 @default.
• W4316672029 cites W2035851552 @default.
• W4316672029 cites W2037486173 @default.
• W4316672029 cites W2040158161 @default.
• W4316672029 cites W2041739600 @default.
• W4316672029 cites W2048258494 @default.
• W4316672029 cites W2075186231 @default.
• W4316672029 cites W2081610020 @default.
• W4316672029 cites W2096091265 @default.
• W4316672029 cites W2101526674 @default.
• W4316672029 cites W2104010513 @default.
• W4316672029 cites W2107890914 @default.
• W4316672029 cites W2113591270 @default.
• W4316672029 cites W2117481455 @default.
• W4316672029 cites W2126792448 @default.
• W4316672029 cites W2166454482 @default.
• W4316672029 cites W2169337437 @default.
• W4316672029 cites W2206527692 @default.
• W4316672029 cites W2742409598 @default.
• W4316672029 cites W2906826986 @default.
• W4316672029 cites W4232574208 @default.
• W4316672029 doi "https://doi.org/10.3389/fimmu.2023.1084056" @default.
• W4316672029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36733483" @default.
• W4316672029 hasPublicationYear "2023" @default.
• W4316672029 type Work @default.
• W4316672029 citedByCount "0" @default.
• W4316672029 crossrefType "journal-article" @default.
• W4316672029 hasAuthorship W4316672029A5002950176 @default.
• W4316672029 hasAuthorship W4316672029A5007547858 @default.
• W4316672029 hasAuthorship W4316672029A5010078682 @default.
• W4316672029 hasAuthorship W4316672029A5020003523 @default.
• W4316672029 hasAuthorship W4316672029A5034836281 @default.
• W4316672029 hasAuthorship W4316672029A5036766747 @default.
• W4316672029 hasAuthorship W4316672029A5040415029 @default.
• W4316672029 hasAuthorship W4316672029A5044556352 @default.
• W4316672029 hasAuthorship W4316672029A5048766021 @default.
• W4316672029 hasAuthorship W4316672029A5059306287 @default.
• W4316672029 hasAuthorship W4316672029A5059374757 @default.
• W4316672029 hasAuthorship W4316672029A5078653342 @default.
• W4316672029 hasBestOaLocation W43166720291 @default.
• W4316672029 hasConcept C104317684 @default.
• W4316672029 hasConcept C109159458 @default.
• W4316672029 hasConcept C134018914 @default.
• W4316672029 hasConcept C142724271 @default.
• W4316672029 hasConcept C151872237 @default.
• W4316672029 hasConcept C185592680 @default.
• W4316672029 hasConcept C18903297 @default.
• W4316672029 hasConcept C203014093 @default.
• W4316672029 hasConcept C2777380497 @default.
• W4316672029 hasConcept C2778764654 @default.
• W4316672029 hasConcept C2780007613 @default.
• W4316672029 hasConcept C28328180 @default.
• W4316672029 hasConcept C2908647359 @default.
• W4316672029 hasConcept C30278631 @default.
• W4316672029 hasConcept C502942594 @default.
• W4316672029 hasConcept C54355233 @default.
• W4316672029 hasConcept C71924100 @default.
• W4316672029 hasConcept C86803240 @default.
• W4316672029 hasConcept C95444343 @default.
• W4316672029 hasConcept C99454951 @default.
• W4316672029 hasConceptScore W4316672029C104317684 @default.
• W4316672029 hasConceptScore W4316672029C109159458 @default.
• W4316672029 hasConceptScore W4316672029C134018914 @default.
• W4316672029 hasConceptScore W4316672029C142724271 @default.
• W4316672029 hasConceptScore W4316672029C151872237 @default.
• W4316672029 hasConceptScore W4316672029C185592680 @default.
• W4316672029 hasConceptScore W4316672029C18903297 @default.
• W4316672029 hasConceptScore W4316672029C203014093 @default.
• W4316672029 hasConceptScore W4316672029C2777380497 @default.
• W4316672029 hasConceptScore W4316672029C2778764654 @default.
• W4316672029 hasConceptScore W4316672029C2780007613 @default.
• W4316672029 hasConceptScore W4316672029C28328180 @default.
• W4316672029 hasConceptScore W4316672029C2908647359 @default.
• W4316672029 hasConceptScore W4316672029C30278631 @default.

• next