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• W4316673014 endingPage "475" @default.
• W4316673014 startingPage "475" @default.
• W4316673014 abstract "The enhanced consumption of fructose as added sugar represents a major health concern. Due to the complexity and multiplicity of hypothalamic functions, we aim to point out early molecular alterations triggered by a sugar-rich diet throughout adolescence, and to verify their persistence until the young adulthood phase.Thirty days old rats received a high-fructose or control diet for 3 weeks. At the end of the experimental period, treated animals were switched to the control diet for further 3 weeks, and then analyzed in comparison with those that were fed the control diet for the entire experimental period.Quantitative proteomics identified 19 differentially represented proteins, between control and fructose-fed groups, belonging to intermediate filament cytoskeleton, neurofilament, pore complex and mitochondrial respiratory chain complexes. Western blotting analysis confirmed proteomic data, evidencing a decreased abundance of mitochondrial respiratory complexes and voltage-dependent anion channel 1, the coregulator of mitochondrial biogenesis PGC-1α, and the protein subunit of neurofilaments α-internexin in fructose-fed rats. Diet-associated hypothalamic inflammation was also detected. Finally, the amount of brain-derived neurotrophic factor and its high-affinity receptor TrkB, as well as of synaptophysin, synaptotagmin, and post-synaptic protein PSD-95 was reduced in sugar-fed rats. Notably, deregulated levels of all proteins were fully rescued after switching to the control diet.A short-term fructose-rich diet in adolescent rats induces hypothalamic inflammation and highly affects mitochondrial and cytoskeletal compartments, as well as the level of specific markers of brain function; above-reported effects are reverted after switching animals to the control diet." @default.
• W4316673014 created "2023-01-17" @default.
• W4316673014 creator A5023216490 @default.
• W4316673014 creator A5052104966 @default.
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• W4316673014 creator A5086600006 @default.
• W4316673014 date "2023-01-16" @default.
• W4316673014 modified "2023-09-26" @default.
• W4316673014 title "Fructose Diet-Associated Molecular Alterations in Hypothalamus of Adolescent Rats: A Proteomic Approach" @default.
• W4316673014 cites W1513719789 @default.
• W4316673014 cites W158119579 @default.
• W4316673014 cites W1752819622 @default.
• W4316673014 cites W1803267321 @default.
• W4316673014 cites W1958940860 @default.
• W4316673014 cites W1966833070 @default.
• W4316673014 cites W1971082641 @default.
• W4316673014 cites W1974541996 @default.
• W4316673014 cites W1974802955 @default.
• W4316673014 cites W1976351218 @default.
• W4316673014 cites W1982345208 @default.
• W4316673014 cites W1987522796 @default.
• W4316673014 cites W1995354490 @default.
• W4316673014 cites W2000223779 @default.
• W4316673014 cites W2002303007 @default.
• W4316673014 cites W2004632368 @default.
• W4316673014 cites W2009861981 @default.
• W4316673014 cites W2018427433 @default.
• W4316673014 cites W2022726058 @default.
• W4316673014 cites W2028680679 @default.
• W4316673014 cites W2028998458 @default.
• W4316673014 cites W2034637290 @default.
• W4316673014 cites W2036943768 @default.
• W4316673014 cites W2044444144 @default.
• W4316673014 cites W2054049367 @default.
• W4316673014 cites W2055667548 @default.
• W4316673014 cites W2060129133 @default.
• W4316673014 cites W2061343421 @default.
• W4316673014 cites W2063546126 @default.
• W4316673014 cites W2073614451 @default.
• W4316673014 cites W2077708785 @default.
• W4316673014 cites W2081258545 @default.
• W4316673014 cites W2082425146 @default.
• W4316673014 cites W2094972439 @default.
• W4316673014 cites W2095964790 @default.
• W4316673014 cites W2097672374 @default.
• W4316673014 cites W2105744572 @default.
• W4316673014 cites W2105754268 @default.
• W4316673014 cites W2106401737 @default.
• W4316673014 cites W2107218401 @default.
• W4316673014 cites W2108326484 @default.
• W4316673014 cites W2119754857 @default.
• W4316673014 cites W2122946015 @default.
• W4316673014 cites W2128276881 @default.
• W4316673014 cites W2134041954 @default.
• W4316673014 cites W2140020251 @default.
• W4316673014 cites W2143588920 @default.
• W4316673014 cites W2146458296 @default.
• W4316673014 cites W2147527484 @default.
• W4316673014 cites W2149623878 @default.
• W4316673014 cites W2150143378 @default.
• W4316673014 cites W2151074651 @default.
• W4316673014 cites W2155481474 @default.
• W4316673014 cites W2168729166 @default.
• W4316673014 cites W2209640119 @default.
• W4316673014 cites W2259137923 @default.
• W4316673014 cites W2330555051 @default.
• W4316673014 cites W2342210027 @default.
• W4316673014 cites W2488589529 @default.
• W4316673014 cites W2505156051 @default.
• W4316673014 cites W2555953028 @default.
• W4316673014 cites W2592741634 @default.
• W4316673014 cites W2604133403 @default.
• W4316673014 cites W2604210857 @default.
• W4316673014 cites W2609760481 @default.
• W4316673014 cites W2610698906 @default.
• W4316673014 cites W2624853583 @default.
• W4316673014 cites W2626122684 @default.
• W4316673014 cites W2733951407 @default.
• W4316673014 cites W2751062939 @default.
• W4316673014 cites W2756324351 @default.
• W4316673014 cites W2761962880 @default.
• W4316673014 cites W2783159957 @default.
• W4316673014 cites W2783446710 @default.
• W4316673014 cites W2788821298 @default.
• W4316673014 cites W2789268007 @default.
• W4316673014 cites W2791105356 @default.
• W4316673014 cites W2804878948 @default.
• W4316673014 cites W2883692834 @default.
• W4316673014 cites W2884885858 @default.
• W4316673014 cites W2905987070 @default.
• W4316673014 cites W2914788692 @default.
• W4316673014 cites W2923075919 @default.
• W4316673014 cites W2946576609 @default.
• W4316673014 cites W2969993959 @default.

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