Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316673023> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4316673023 endingPage "565" @default.
- W4316673023 startingPage "551" @default.
- W4316673023 abstract "Recent research reported that lurasidone degrades in unpreserved ante-mortem human whole blood inoculated with microorganisms known to dominate postmortem blood specimens. In vitro degradation occurred at a similar rate to risperidone, known to degrade in authentic postmortem specimens until below analytical detection limits. To identify the lurasidone degradation products formed, an Agilent 6520 liquid chromatograph quadrupole-time-of-flight mass spectrometer (LC-QTOF-MS) operating in auto-MS/MS mode was used. Numerous degradation products not previously reported in prior in vitro or in vivo pharmacokinetic studies or forced degradation studies were detected. Accurate mass data, mass fragmentation data, acetylation experiments, and a proposed mechanism of degradation analogous to risperidone supports initial identification of the major degradation product as N-debenzisothiazole-lurasidone (calculated m/z [M + H]+ = 360.2646). A standard was unavailable to conclusively confirm this identification. Retrospective data analysis of postmortem cases involving lurasidone identified the presence of the major degradation product in four of six cases where lurasidone was also detected. This finding is significant for toxicology laboratories screening for this drug in postmortem casework. The major postmortem lurasidone degradation product has consequently been added to the LC-QTOF-MS drug screen at Forensic Science SA (FSSA) to indicate postmortem lurasidone degradation in authentic postmortem blood specimens and as a marker of lurasidone administration in the event lurasidone is degraded to concentrations below detection limits." @default.
- W4316673023 created "2023-01-17" @default.
- W4316673023 creator A5007139358 @default.
- W4316673023 creator A5017540365 @default.
- W4316673023 creator A5024092288 @default.
- W4316673023 creator A5037651436 @default.
- W4316673023 creator A5038131092 @default.
- W4316673023 creator A5076066190 @default.
- W4316673023 creator A5077651627 @default.
- W4316673023 date "2023-01-29" @default.
- W4316673023 modified "2023-09-26" @default.
- W4316673023 title "Microbial degradation products of lurasidone and their significance in postmortem toxicology" @default.
- W4316673023 cites W113902470 @default.
- W4316673023 cites W1599227262 @default.
- W4316673023 cites W1980071307 @default.
- W4316673023 cites W1993962470 @default.
- W4316673023 cites W2043452239 @default.
- W4316673023 cites W2050772218 @default.
- W4316673023 cites W2108130592 @default.
- W4316673023 cites W2325010177 @default.
- W4316673023 cites W2338360656 @default.
- W4316673023 cites W2461594029 @default.
- W4316673023 cites W2604285331 @default.
- W4316673023 cites W2744649092 @default.
- W4316673023 cites W2754663919 @default.
- W4316673023 cites W2763334950 @default.
- W4316673023 cites W2765752275 @default.
- W4316673023 cites W2784239040 @default.
- W4316673023 cites W2807609672 @default.
- W4316673023 cites W3012051344 @default.
- W4316673023 cites W4213033819 @default.
- W4316673023 cites W4281687221 @default.
- W4316673023 doi "https://doi.org/10.1002/dta.3441" @default.
- W4316673023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36647693" @default.
- W4316673023 hasPublicationYear "2023" @default.
- W4316673023 type Work @default.
- W4316673023 citedByCount "0" @default.
- W4316673023 crossrefType "journal-article" @default.
- W4316673023 hasAuthorship W4316673023A5007139358 @default.
- W4316673023 hasAuthorship W4316673023A5017540365 @default.
- W4316673023 hasAuthorship W4316673023A5024092288 @default.
- W4316673023 hasAuthorship W4316673023A5037651436 @default.
- W4316673023 hasAuthorship W4316673023A5038131092 @default.
- W4316673023 hasAuthorship W4316673023A5076066190 @default.
- W4316673023 hasAuthorship W4316673023A5077651627 @default.
- W4316673023 hasBestOaLocation W43166730231 @default.
- W4316673023 hasConcept C118552586 @default.
- W4316673023 hasConcept C185592680 @default.
- W4316673023 hasConcept C2776412080 @default.
- W4316673023 hasConcept C2776701107 @default.
- W4316673023 hasConcept C2780494398 @default.
- W4316673023 hasConcept C43617362 @default.
- W4316673023 hasConcept C71924100 @default.
- W4316673023 hasConcept C98274493 @default.
- W4316673023 hasConceptScore W4316673023C118552586 @default.
- W4316673023 hasConceptScore W4316673023C185592680 @default.
- W4316673023 hasConceptScore W4316673023C2776412080 @default.
- W4316673023 hasConceptScore W4316673023C2776701107 @default.
- W4316673023 hasConceptScore W4316673023C2780494398 @default.
- W4316673023 hasConceptScore W4316673023C43617362 @default.
- W4316673023 hasConceptScore W4316673023C71924100 @default.
- W4316673023 hasConceptScore W4316673023C98274493 @default.
- W4316673023 hasFunder F4320315501 @default.
- W4316673023 hasIssue "5" @default.
- W4316673023 hasLocation W43166730231 @default.
- W4316673023 hasLocation W43166730232 @default.
- W4316673023 hasOpenAccess W4316673023 @default.
- W4316673023 hasPrimaryLocation W43166730231 @default.
- W4316673023 hasRelatedWork W1531601525 @default.
- W4316673023 hasRelatedWork W1673495827 @default.
- W4316673023 hasRelatedWork W1729743715 @default.
- W4316673023 hasRelatedWork W2461594029 @default.
- W4316673023 hasRelatedWork W2748952813 @default.
- W4316673023 hasRelatedWork W2899084033 @default.
- W4316673023 hasRelatedWork W2948807893 @default.
- W4316673023 hasRelatedWork W4317396727 @default.
- W4316673023 hasRelatedWork W4378173498 @default.
- W4316673023 hasRelatedWork W2778153218 @default.
- W4316673023 hasVolume "15" @default.
- W4316673023 isParatext "false" @default.
- W4316673023 isRetracted "false" @default.
- W4316673023 workType "article" @default.