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• W4316673589 abstract "Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by cytosolic ribosomes. Many of these ribosomes are localized in the vicinity of the functional site of their encoded protein, enabling local protein synthesis. Studies in various organisms and tissues revealed that such locally translating ribosomes are also present near mitochondria. Here, we provide a brief summary of evidence for localized translation near mitochondria, then present data suggesting that these localized ribosomes may enable local translational regulatory processes in response to mitochondria needs. Finally, we describe the involvement of such localized ribosomes in the quality control of protein synthesis and mitochondria. These emerging views suggest that ribosomes localized near mitochondria are a hub for a variety of activities with diverse implications on mitochondria physiology." @default.
• W4316673589 created "2023-01-17" @default.
• W4316673589 creator A5017320785 @default.
• W4316673589 creator A5034705017 @default.
• W4316673589 creator A5030445748 @default.
• W4316673589 date "2023-01-01" @default.
• W4316673589 modified "2023-10-02" @default.
• W4316673589 title "Emerging implications for ribosomes in proximity to mitochondria" @default.
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• W4316673589 doi "https://doi.org/10.1016/j.semcdb.2023.01.003" @default.
• W4316673589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36642616" @default.
• W4316673589 hasPublicationYear "2023" @default.
• W4316673589 type Work @default.
• W4316673589 citedByCount "1" @default.

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