FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316805150> ?p ?o ?g. }

• W4316805150 abstract "Depression and anxiety are common diseases that endanger the physical and mental health of individuals. Agarwood incense inhalation has been used as a traditional Chinese medicine for relaxation and to improve sleep for centuries. In a previous study by the authors it was demonstrated that agarwood essential oil (AEO) injection exerted anxiolytic and antidepressant effects. Therefore the present study further investigated the anxiolytic and antidepressant effects of AEO inhalation on anxiolytic mice induced by M‑chlorophenylpiperazine and depressive mice induced by chronic unpredictable mild stress. The results demonstrated that AEO exerted a significant anxiolytic effect, whereby autonomous movements were inhibited during the light dark exploration test and open field test. Furthermore, the tail suspension test and the forced swimming test demonstrated that AEO also exerted an antidepressant effect, whereby the immobility times were decreased. Moreover, AEO was determined to increase the levels of 5‑hydroxytryptamine, γ‑aminobutyric acid (GABA) A receptor (GABAA) and glutamate (Glu) in anxiolytic mice and inhibit the levels of GABAA and Glu in depressive mice. Further investigations into how AEO affected the Glu/GABA system demonstrated that AEO markedly increased the protein expression levels of GABA transaminase (GABAT), glutamate metabotropic receptor 5 (GRM5), glutamate ionotropic receptor AMPA type subunit 1 (GluR1) and vesicular glutamate transporter 1 (VGluT1). Furthermore, AEO reduced the expression levels of GABAT, glutamate ionotropic receptor NMDA type subunit 2B and GRM5, and enhanced the expression levels of GluR1 and VGluT1. These results demonstrated that AEO potentially possesses antianxiety and antidepressant properties. The present study determined that the mechanism was related to the regulation of Glu/GABA neurotransmitter system homeostasis." @default.
• W4316805150 created "2023-01-17" @default.
• W4316805150 creator A5012656620 @default.
• W4316805150 creator A5028794611 @default.
• W4316805150 creator A5047187328 @default.
• W4316805150 creator A5048030199 @default.
• W4316805150 creator A5086831639 @default.
• W4316805150 creator A5091097200 @default.
• W4316805150 date "2023-01-17" @default.
• W4316805150 modified "2023-10-03" @default.
• W4316805150 title "Agarwood essential oil inhalation exerts antianxiety and antidepressant effects via the regulation of Glu/GABA system homeostasis" @default.
• W4316805150 cites W1187204867 @default.
• W4316805150 cites W1629950689 @default.
• W4316805150 cites W1973076339 @default.
• W4316805150 cites W1977056557 @default.
• W4316805150 cites W1977184712 @default.
• W4316805150 cites W1980383041 @default.
• W4316805150 cites W1980885144 @default.
• W4316805150 cites W1993254026 @default.
• W4316805150 cites W1996092905 @default.
• W4316805150 cites W2003760083 @default.
• W4316805150 cites W2010526028 @default.
• W4316805150 cites W2018823558 @default.
• W4316805150 cites W2043713804 @default.
• W4316805150 cites W2047431955 @default.
• W4316805150 cites W2066265887 @default.
• W4316805150 cites W2068880746 @default.
• W4316805150 cites W2071967920 @default.
• W4316805150 cites W2076563741 @default.
• W4316805150 cites W2085042184 @default.
• W4316805150 cites W2096494544 @default.
• W4316805150 cites W2104834189 @default.
• W4316805150 cites W2146006615 @default.
• W4316805150 cites W2150850420 @default.
• W4316805150 cites W2153227444 @default.
• W4316805150 cites W2157504436 @default.
• W4316805150 cites W2163032431 @default.
• W4316805150 cites W2282843413 @default.
• W4316805150 cites W2291902826 @default.
• W4316805150 cites W2308287779 @default.
• W4316805150 cites W2313639050 @default.
• W4316805150 cites W2466163829 @default.
• W4316805150 cites W2595110790 @default.
• W4316805150 cites W2762954760 @default.
• W4316805150 cites W2765160570 @default.
• W4316805150 cites W2768811819 @default.
• W4316805150 cites W2774286094 @default.
• W4316805150 cites W2780895578 @default.
• W4316805150 cites W2793059673 @default.
• W4316805150 cites W2809546062 @default.
• W4316805150 cites W2899896289 @default.
• W4316805150 cites W3010673072 @default.
• W4316805150 cites W3016280934 @default.
• W4316805150 doi "https://doi.org/10.3892/br.2023.1598" @default.
• W4316805150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36776581" @default.
• W4316805150 hasPublicationYear "2023" @default.
• W4316805150 type Work @default.
• W4316805150 citedByCount "0" @default.
• W4316805150 crossrefType "journal-article" @default.
• W4316805150 hasAuthorship W4316805150A5012656620 @default.
• W4316805150 hasAuthorship W4316805150A5028794611 @default.
• W4316805150 hasAuthorship W4316805150A5047187328 @default.
• W4316805150 hasAuthorship W4316805150A5048030199 @default.
• W4316805150 hasAuthorship W4316805150A5086831639 @default.
• W4316805150 hasAuthorship W4316805150A5091097200 @default.
• W4316805150 hasBestOaLocation W43168051501 @default.
• W4316805150 hasConcept C115955781 @default.
• W4316805150 hasConcept C118552586 @default.
• W4316805150 hasConcept C126322002 @default.
• W4316805150 hasConcept C136569192 @default.
• W4316805150 hasConcept C142724271 @default.
• W4316805150 hasConcept C168258287 @default.
• W4316805150 hasConcept C170493617 @default.
• W4316805150 hasConcept C173586616 @default.
• W4316805150 hasConcept C181199279 @default.
• W4316805150 hasConcept C185592680 @default.
• W4316805150 hasConcept C204787440 @default.
• W4316805150 hasConcept C2777421860 @default.
• W4316805150 hasConcept C2777765862 @default.
• W4316805150 hasConcept C2778706202 @default.
• W4316805150 hasConcept C2779085643 @default.
• W4316805150 hasConcept C2779177272 @default.
• W4316805150 hasConcept C2781001258 @default.
• W4316805150 hasConcept C2781161787 @default.
• W4316805150 hasConcept C49051014 @default.
• W4316805150 hasConcept C55493867 @default.
• W4316805150 hasConcept C558461103 @default.
• W4316805150 hasConcept C61174792 @default.
• W4316805150 hasConcept C71924100 @default.
• W4316805150 hasConcept C9497952 @default.
• W4316805150 hasConcept C98274493 @default.
• W4316805150 hasConceptScore W4316805150C115955781 @default.
• W4316805150 hasConceptScore W4316805150C118552586 @default.
• W4316805150 hasConceptScore W4316805150C126322002 @default.
• W4316805150 hasConceptScore W4316805150C136569192 @default.
• W4316805150 hasConceptScore W4316805150C142724271 @default.
• W4316805150 hasConceptScore W4316805150C168258287 @default.
• W4316805150 hasConceptScore W4316805150C170493617 @default.
• W4316805150 hasConceptScore W4316805150C173586616 @default.
• W4316805150 hasConceptScore W4316805150C181199279 @default.

• next