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- W4316814827 abstract "Mankind's quest for a manned mission to Mars is placing increased emphasis on the development of innovative radio-protective countermeasures for long-term space travel. Hibernation confers radio-protective effects in hibernating animals, and this has led to the investigation of synthetic torpor to mitigate the deleterious effects of chronic low-dose-rate radiation exposure. Here we describe an induced torpor model we developed using the zebrafish. We explored the effects of radiation exposure on this model with a focus on the liver. Transcriptomic and behavioural analyses were performed. Radiation exposure resulted in transcriptomic perturbations in lipid metabolism and absorption, wound healing, immune response, and fibrogenic pathways. Induced torpor reduced metabolism and increased pro-survival, anti-apoptotic, and DNA repair pathways. Coupled with radiation exposure, induced torpor led to a stress response but also revealed maintenance of DNA repair mechanisms, pro-survival and anti-apoptotic signals. To further characterise our model of induced torpor, the zebrafish model was compared with hepatic transcriptomic data from hibernating grizzly bears (Ursus arctos horribilis) and active controls revealing conserved responses in gene expression associated with anti-apoptotic processes, DNA damage repair, cell survival, proliferation, and antioxidant response. Similarly, the radiation group was compared with space-flown mice revealing shared changes in lipid metabolism." @default.
- W4316814827 created "2023-01-17" @default.
- W4316814827 creator A5005084000 @default.
- W4316814827 creator A5016505833 @default.
- W4316814827 creator A5030396955 @default.
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- W4316814827 creator A5039444207 @default.
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- W4316814827 creator A5080810068 @default.
- W4316814827 creator A5087882161 @default.
- W4316814827 date "2023-01-17" @default.
- W4316814827 modified "2023-09-26" @default.
- W4316814827 title "Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model" @default.
- W4316814827 cites W126327997 @default.
- W4316814827 cites W1489679817 @default.
- W4316814827 cites W1499746055 @default.
- W4316814827 cites W1527099325 @default.
- W4316814827 cites W1777506287 @default.
- W4316814827 cites W1913169768 @default.
- W4316814827 cites W1968493165 @default.
- W4316814827 cites W1968846453 @default.
- W4316814827 cites W1971258591 @default.
- W4316814827 cites W1977161523 @default.
- W4316814827 cites W1988856237 @default.
- W4316814827 cites W1994540097 @default.
- W4316814827 cites W1994963220 @default.
- W4316814827 cites W1994988324 @default.
- W4316814827 cites W1998068133 @default.
- W4316814827 cites W1998735049 @default.
- W4316814827 cites W2005709221 @default.
- W4316814827 cites W2007987759 @default.
- W4316814827 cites W2009119978 @default.
- W4316814827 cites W2010962756 @default.
- W4316814827 cites W2010985641 @default.
- W4316814827 cites W2011283339 @default.
- W4316814827 cites W2017729871 @default.
- W4316814827 cites W2022501326 @default.
- W4316814827 cites W2023637447 @default.
- W4316814827 cites W2023946408 @default.
- W4316814827 cites W2028680278 @default.
- W4316814827 cites W2032019813 @default.
- W4316814827 cites W2032878070 @default.
- W4316814827 cites W2033528620 @default.
- W4316814827 cites W2034325831 @default.
- W4316814827 cites W2036897871 @default.
- W4316814827 cites W2042889829 @default.
- W4316814827 cites W2052024305 @default.
- W4316814827 cites W2055034178 @default.
- W4316814827 cites W2062171951 @default.
- W4316814827 cites W2064310817 @default.
- W4316814827 cites W2064675388 @default.
- W4316814827 cites W2065840120 @default.
- W4316814827 cites W2066694823 @default.
- W4316814827 cites W2066839216 @default.
- W4316814827 cites W2066919199 @default.
- W4316814827 cites W2068559679 @default.
- W4316814827 cites W2069992071 @default.
- W4316814827 cites W2082319637 @default.
- W4316814827 cites W2093157637 @default.
- W4316814827 cites W2095068161 @default.
- W4316814827 cites W2096173332 @default.
- W4316814827 cites W2096916192 @default.
- W4316814827 cites W2097890124 @default.
- W4316814827 cites W2097948046 @default.
- W4316814827 cites W2101465904 @default.
- W4316814827 cites W2101858768 @default.
- W4316814827 cites W2104452138 @default.
- W4316814827 cites W2105714694 @default.
- W4316814827 cites W2110256992 @default.
- W4316814827 cites W2110980549 @default.
- W4316814827 cites W2111185907 @default.
- W4316814827 cites W2115683123 @default.
- W4316814827 cites W2116951020 @default.
- W4316814827 cites W2124649657 @default.
- W4316814827 cites W2134526812 @default.
- W4316814827 cites W2139697423 @default.
- W4316814827 cites W2142450713 @default.
- W4316814827 cites W2142656259 @default.
- W4316814827 cites W2145757122 @default.
- W4316814827 cites W2154972152 @default.
- W4316814827 cites W2155243243 @default.
- W4316814827 cites W2156449330 @default.
- W4316814827 cites W2157177585 @default.
- W4316814827 cites W2159675211 @default.
- W4316814827 cites W2168652839 @default.
- W4316814827 cites W2168744563 @default.
- W4316814827 cites W2169456326 @default.
- W4316814827 cites W2179438025 @default.
- W4316814827 cites W2264959907 @default.
- W4316814827 cites W2339163193 @default.
- W4316814827 cites W2343583896 @default.
- W4316814827 cites W2411700095 @default.
- W4316814827 cites W2412031353 @default.
- W4316814827 cites W2464287880 @default.
- W4316814827 cites W2518846963 @default.
- W4316814827 cites W2606109289 @default.
- W4316814827 cites W2755231468 @default.
- W4316814827 cites W2761134105 @default.
- W4316814827 cites W2765230669 @default.