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- W4316814842 abstract "Reactive oxygen species (ROS) are constant by-products of aerobic life. In excess, ROS lead to cytotoxic protein aggregates, which are a hallmark of ageing in animals and linked to age-related pathologies in humans. Acylamino acid-releasing enzymes (AARE) are bifunctional serine proteases, acting on oxidized proteins. AARE are found in all domains of life, albeit under different names, such as acylpeptide hydrolase (APEH/ACPH), acylaminoacyl peptidase (AAP), or oxidized protein hydrolase (OPH). In humans, AARE malfunction is associated with age-related pathologies, while their function in plants is less clear. Here, we provide a detailed analysis of AARE genes in the plant lineage and an in-depth analysis of AARE localization and function in the moss Physcomitrella and the angiosperm Arabidopsis. AARE loss-of-function mutants have not been described for any organism so far. We generated and analysed such mutants and describe a connection between AARE function, aggregation of oxidized proteins and plant ageing, including accelerated developmental progression and reduced life span. Our findings complement similar findings in animals and humans, and suggest a unified concept of ageing may exist in different life forms." @default.
- W4316814842 created "2023-01-17" @default.
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- W4316814842 date "2023-01-17" @default.
- W4316814842 modified "2023-10-18" @default.
- W4316814842 title "A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in ageing in Physcomitrella and Arabidopsis" @default.
- W4316814842 cites W1748508858 @default.
- W4316814842 cites W1762061589 @default.
- W4316814842 cites W1783499490 @default.
- W4316814842 cites W1814964070 @default.
- W4316814842 cites W1861483195 @default.
- W4316814842 cites W1925651000 @default.
- W4316814842 cites W1964952835 @default.
- W4316814842 cites W1967003637 @default.
- W4316814842 cites W1971439989 @default.
- W4316814842 cites W1973425212 @default.
- W4316814842 cites W1976276572 @default.
- W4316814842 cites W1977027195 @default.
- W4316814842 cites W1978536046 @default.
- W4316814842 cites W1978849279 @default.
- W4316814842 cites W1980019714 @default.
- W4316814842 cites W1980075732 @default.
- W4316814842 cites W1980431043 @default.
- W4316814842 cites W1981015328 @default.
- W4316814842 cites W1982647833 @default.
- W4316814842 cites W1984243890 @default.
- W4316814842 cites W1985868314 @default.
- W4316814842 cites W1986475036 @default.
- W4316814842 cites W1986741701 @default.
- W4316814842 cites W1988006507 @default.
- W4316814842 cites W1993658132 @default.
- W4316814842 cites W1994685997 @default.
- W4316814842 cites W1995644529 @default.
- W4316814842 cites W1998484135 @default.
- W4316814842 cites W2003748109 @default.
- W4316814842 cites W2007977190 @default.
- W4316814842 cites W2013955803 @default.
- W4316814842 cites W2019438362 @default.
- W4316814842 cites W2021795499 @default.
- W4316814842 cites W2036181141 @default.
- W4316814842 cites W2036934557 @default.
- W4316814842 cites W2039731523 @default.
- W4316814842 cites W2044714169 @default.
- W4316814842 cites W2045071699 @default.
- W4316814842 cites W2046183549 @default.
- W4316814842 cites W2046347466 @default.
- W4316814842 cites W2046987173 @default.
- W4316814842 cites W2049546907 @default.
- W4316814842 cites W2052971459 @default.
- W4316814842 cites W2061226620 @default.
- W4316814842 cites W2065388739 @default.
- W4316814842 cites W2066644392 @default.
- W4316814842 cites W2068337326 @default.
- W4316814842 cites W2071783223 @default.
- W4316814842 cites W2072285646 @default.
- W4316814842 cites W2076016822 @default.
- W4316814842 cites W2080669759 @default.
- W4316814842 cites W2080752012 @default.
- W4316814842 cites W2086115184 @default.
- W4316814842 cites W2089370159 @default.
- W4316814842 cites W2090648171 @default.
- W4316814842 cites W2094441238 @default.
- W4316814842 cites W2096724410 @default.
- W4316814842 cites W2105275962 @default.
- W4316814842 cites W2105538672 @default.
- W4316814842 cites W2109324504 @default.
- W4316814842 cites W2120239584 @default.
- W4316814842 cites W2121087319 @default.
- W4316814842 cites W2121639904 @default.
- W4316814842 cites W2121900206 @default.
- W4316814842 cites W2125346198 @default.
- W4316814842 cites W2126392233 @default.
- W4316814842 cites W2126525177 @default.
- W4316814842 cites W2128635872 @default.
- W4316814842 cites W2129797991 @default.
- W4316814842 cites W2134724878 @default.
- W4316814842 cites W2135230723 @default.
- W4316814842 cites W2141052558 @default.
- W4316814842 cites W2141512206 @default.
- W4316814842 cites W2145637864 @default.
- W4316814842 cites W2157517423 @default.
- W4316814842 cites W2158714788 @default.
- W4316814842 cites W2165276694 @default.
- W4316814842 cites W2167603163 @default.
- W4316814842 cites W2168491820 @default.
- W4316814842 cites W2170262566 @default.
- W4316814842 cites W2170566884 @default.