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- W4316829820 abstract "To maintain renewing epithelial tissues in a healthy, homeostatic state, (stem) cell divisions and differentiation need to be tightly regulated. Mechanisms of homeostatic control often rely on crowding control: cells are able to sense the cell density in their environment (via various molecular and mechanosensing pathways) and respond by adjusting division, differentiation, and cell state transitions appropriately. Here we determine, via a mathematically rigorous framework, which general conditions for the crowding feedback regulation (i) must be minimally met, and (ii) are sufficient, to allow the maintenance of homeostasis in renewing tissues. We show that those conditions naturally allow for a degree of robustness toward disruption of regulation. Furthermore, intrinsic to this feedback regulation is that stem cell identity is established collectively by the cell population, not by individual cells, which implies the possibility of `quasi-dedifferentiation', in which cells committed to differentiation may reacquire stem cell properties upon depletion of the stem cell pool. These findings can guide future experimental campaigns to identify specific crowding feedback mechanisms." @default.
- W4316829820 created "2023-01-17" @default.
- W4316829820 creator A5054426273 @default.
- W4316829820 creator A5081782855 @default.
- W4316829820 date "2023-01-12" @default.
- W4316829820 modified "2023-09-25" @default.
- W4316829820 title "Homeostatic regulation of renewing tissue cell populations via crowding control" @default.
- W4316829820 doi "https://doi.org/10.48550/arxiv.2301.05321" @default.
- W4316829820 hasPublicationYear "2023" @default.
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