FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316877127> ?p ?o ?g. }

• W4316877127 endingPage "e0280085" @default.
• W4316877127 startingPage "e0280085" @default.
• W4316877127 abstract "Background Colorectal cancer causes 935,000 cancer deaths yearly. High local immune cell infiltration serves as a positive prognostic factor in CRC. Toll-like receptors (TLRs) induce innate immune responses and lead to adaptive immune system activation. TLRs play protumorigenic and antitumorigenic roles. We aimed to explore the relationship between TLR immunoexpressions and the infiltration densities of T-lymphocytes in CRC. Methods Immunohistochemical TLR2, TLR4, TLR5, and TLR7 positivity and the density of CD3- and CD8-positive cells in tumoral and stromal tissue were evaluated from the tissue microarray slides of 549 consecutive CRC surgical patients treated at Helsinki University Hospital, Finland, between 1998 and 2005. We calculated the associations and correlations using Pearson’s chi-square and Spearman’s correlation tests, generating survival curves using the Kaplan–Meier method. Results Positive intratumoral CD3 and CD8 densities associated with a high TLR2 expression ( p < 0.001 and p = 0.001, respectively) and a high TLR4 expression ( p = 0.013 and p = 0.025). A low TLR5 immunoexpression associated with negative intratumoral CD3 ( p = 0.001) and CD8 ( p = 0.011) and a low stromal CD3 ( p = 0.001). No association or correlation emerged between TLR7 immunoexpression and CD3 or CD8 cell density. A low CD3–CD8 tumor–stroma index indicated a worse prognosis among all TLR subgroups, except the TLR7-negative subgroup. Conclusions We detected significant associations and correlations between high tissue TLR2, TLR4, and TLR5 immunoexpressions and high densities of CD3- and CD8-positive cells. Combining these markers may improve the prognostic evaluation of CRC patients." @default.
• W4316877127 created "2023-01-17" @default.
• W4316877127 creator A5030652209 @default.
• W4316877127 creator A5035651238 @default.
• W4316877127 creator A5045989882 @default.
• W4316877127 creator A5052515539 @default.
• W4316877127 creator A5055369999 @default.
• W4316877127 creator A5085207133 @default.
• W4316877127 date "2023-01-17" @default.
• W4316877127 modified "2023-10-14" @default.
• W4316877127 title "High tissue expression of TLRs combined with high density of tumor infiltrating lymphocytes predicts a better prognosis in colorectal cancer patients" @default.
• W4316877127 cites W1965917728 @default.
• W4316877127 cites W1967954493 @default.
• W4316877127 cites W1988902102 @default.
• W4316877127 cites W1992511639 @default.
• W4316877127 cites W2004630197 @default.
• W4316877127 cites W2004647500 @default.
• W4316877127 cites W2015649564 @default.
• W4316877127 cites W2029199150 @default.
• W4316877127 cites W2048763742 @default.
• W4316877127 cites W2049427909 @default.
• W4316877127 cites W2049491375 @default.
• W4316877127 cites W2051198779 @default.
• W4316877127 cites W2066013154 @default.
• W4316877127 cites W2070618028 @default.
• W4316877127 cites W2083983523 @default.
• W4316877127 cites W2090640877 @default.
• W4316877127 cites W2093940965 @default.
• W4316877127 cites W2095598060 @default.
• W4316877127 cites W2111220263 @default.
• W4316877127 cites W2135986822 @default.
• W4316877127 cites W2144428132 @default.
• W4316877127 cites W2148064544 @default.
• W4316877127 cites W2150633526 @default.
• W4316877127 cites W2157093199 @default.
• W4316877127 cites W2164001237 @default.
• W4316877127 cites W2168203442 @default.
• W4316877127 cites W2168445963 @default.
• W4316877127 cites W2236714868 @default.
• W4316877127 cites W2302003756 @default.
• W4316877127 cites W2342685632 @default.
• W4316877127 cites W2420202036 @default.
• W4316877127 cites W2527832410 @default.
• W4316877127 cites W2608667084 @default.
• W4316877127 cites W2613553789 @default.
• W4316877127 cites W2795718561 @default.
• W4316877127 cites W2809609740 @default.
• W4316877127 cites W2967681225 @default.
• W4316877127 cites W2980903476 @default.
• W4316877127 cites W2985871144 @default.
• W4316877127 cites W3028339836 @default.
• W4316877127 cites W3128646645 @default.
• W4316877127 cites W3171987055 @default.
• W4316877127 cites W3198563715 @default.
• W4316877127 cites W4226041418 @default.
• W4316877127 cites W4239180165 @default.
• W4316877127 doi "https://doi.org/10.1371/journal.pone.0280085" @default.
• W4316877127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36649244" @default.
• W4316877127 hasPublicationYear "2023" @default.
• W4316877127 type Work @default.
• W4316877127 citedByCount "0" @default.
• W4316877127 crossrefType "journal-article" @default.
• W4316877127 hasAuthorship W4316877127A5030652209 @default.
• W4316877127 hasAuthorship W4316877127A5035651238 @default.
• W4316877127 hasAuthorship W4316877127A5045989882 @default.
• W4316877127 hasAuthorship W4316877127A5052515539 @default.
• W4316877127 hasAuthorship W4316877127A5055369999 @default.
• W4316877127 hasAuthorship W4316877127A5085207133 @default.
• W4316877127 hasBestOaLocation W43168771271 @default.
• W4316877127 hasConcept C114684123 @default.
• W4316877127 hasConcept C121608353 @default.
• W4316877127 hasConcept C126322002 @default.
• W4316877127 hasConcept C142724271 @default.
• W4316877127 hasConcept C167672396 @default.
• W4316877127 hasConcept C16930146 @default.
• W4316877127 hasConcept C193270364 @default.
• W4316877127 hasConcept C203014093 @default.
• W4316877127 hasConcept C204232928 @default.
• W4316877127 hasConcept C2776070231 @default.
• W4316877127 hasConcept C2777338127 @default.
• W4316877127 hasConcept C2778326572 @default.
• W4316877127 hasConcept C2781236682 @default.
• W4316877127 hasConcept C502942594 @default.
• W4316877127 hasConcept C526805850 @default.
• W4316877127 hasConcept C71924100 @default.
• W4316877127 hasConcept C86803240 @default.
• W4316877127 hasConcept C8891405 @default.
• W4316877127 hasConceptScore W4316877127C114684123 @default.
• W4316877127 hasConceptScore W4316877127C121608353 @default.
• W4316877127 hasConceptScore W4316877127C126322002 @default.
• W4316877127 hasConceptScore W4316877127C142724271 @default.
• W4316877127 hasConceptScore W4316877127C167672396 @default.
• W4316877127 hasConceptScore W4316877127C16930146 @default.
• W4316877127 hasConceptScore W4316877127C193270364 @default.
• W4316877127 hasConceptScore W4316877127C203014093 @default.
• W4316877127 hasConceptScore W4316877127C204232928 @default.
• W4316877127 hasConceptScore W4316877127C2776070231 @default.
• W4316877127 hasConceptScore W4316877127C2777338127 @default.

• next