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• W4316927882 abstract "Gliomas are the most frequent primary tumors of the brain. Glioma progression is regulated by the tumor microenvironment, which is mainly composed of tumor-associated microglia (TA-MG) and monocyte-derived macrophages (MDM). Recent studies have highlighted the distinct properties of these cells in glioma progression. However, their spatiotemporal alteration during tumor progression has not been fully explored. Using a genetic lineage tracing approach, we show that TA-MG and MDMs differ in their spatiotemporal distribution and interaction with other components of the glioma microenvironment. MDM were present only inside the tumor, whereas TA-MG accumulated both outside and inside the tumor. However, TA-MG was eliminated from the tumor mass as the tumor progressed. Depletion of MDM led to enhanced occupancy of TA-MG in the tumor core, indicating that TA-MG elimination was regulated by MDM. TA-MG and MDM are heterogeneous cell populations whose compositions and properties can change during tumor progression. Finally, MG, TA-MG and MDM were enriched in the perivascular area (PVA) compared to more distal blood vessel-associated areas. However, inside the tumor, the MDM enrichment in PVA was higher than that in TA-MG. Collectively, we established that TA-MG and MDM exhibit different spatiotemporal features in glioma, suggesting distinctive roles during tumor progression." @default.
• W4316927882 created "2023-01-18" @default.
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• W4316927882 date "2023-02-05" @default.
• W4316927882 modified "2023-10-11" @default.
• W4316927882 title "Distinct spatiotemporal features of microglia and monocyte‐derived macrophages in glioma" @default.
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• W4316927882 doi "https://doi.org/10.1002/eji.202250161" @default.
• W4316927882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36649079" @default.
• W4316927882 hasPublicationYear "2023" @default.
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