Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317042446> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4317042446 abstract "Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that prompts immediate potent treatment. Delaying treatment could leave debilitating sequelae. As erythropoietin (EPO) has shown neuroprotective effects, we studied the effects of adding EPO to intravenous methylprednisolone (IVMP) in patients with acute attacks of NMOSD.
 Methods: NMOSD cases with acute attacks were included. Cases of optic neuritis (ON) and those with myelitis were separated. After randomization [with block sizes of 2 (1:1 ratio)], the patients in the intervention group received IVMP 1000 mg/day and intravenous (IV) EPO 20000 U/day for five days. IVMP 1000 mg/day and normal saline (NS) were administered in the control group. Staged eye score and motor forces were evaluated in the patients with ON and myelitis, respectively, at the time of the attack and three months later. Primary patient allocation and clinical assessments were blinded to the physicians.
 Results: Mean age of participants was 53.87 ± 11.53 years. At follow-up, in the ON arm, the median improvement in staged eye score was 2 in the control and 5 in the intervention group. The difference was significant (P < 0.001). In the myelitis group, none of the patients in the control group had improvement in motor forces. All the patients in the intervention group showed substantial improvement with minimal or no remaining weakness. The difference was statistically significant (P = 0.029).
 Conclusion: The results show the possible benefit of adding EPO to the classic IVMP in attacks of NMOSD in both visual and motor aspects." @default.
- W4317042446 created "2023-01-18" @default.
- W4317042446 creator A5011484213 @default.
- W4317042446 creator A5037659214 @default.
- W4317042446 creator A5045413854 @default.
- W4317042446 creator A5079111023 @default.
- W4317042446 creator A5088983454 @default.
- W4317042446 creator A5091651650 @default.
- W4317042446 date "2023-01-17" @default.
- W4317042446 modified "2023-10-14" @default.
- W4317042446 title "Adding erythropoietin to intravenous methylprednisolone in acute treatment of attacks of neuromyelitis optica spectrum disorders: A randomized controlled trial" @default.
- W4317042446 doi "https://doi.org/10.18502/cjn.v21i4.11715" @default.
- W4317042446 hasPublicationYear "2023" @default.
- W4317042446 type Work @default.
- W4317042446 citedByCount "0" @default.
- W4317042446 crossrefType "journal-article" @default.
- W4317042446 hasAuthorship W4317042446A5011484213 @default.
- W4317042446 hasAuthorship W4317042446A5037659214 @default.
- W4317042446 hasAuthorship W4317042446A5045413854 @default.
- W4317042446 hasAuthorship W4317042446A5079111023 @default.
- W4317042446 hasAuthorship W4317042446A5088983454 @default.
- W4317042446 hasAuthorship W4317042446A5091651650 @default.
- W4317042446 hasBestOaLocation W43170424461 @default.
- W4317042446 hasConcept C118552586 @default.
- W4317042446 hasConcept C126322002 @default.
- W4317042446 hasConcept C141071460 @default.
- W4317042446 hasConcept C168563851 @default.
- W4317042446 hasConcept C187212893 @default.
- W4317042446 hasConcept C204243189 @default.
- W4317042446 hasConcept C2776572573 @default.
- W4317042446 hasConcept C2777704947 @default.
- W4317042446 hasConcept C2778534260 @default.
- W4317042446 hasConcept C2780372218 @default.
- W4317042446 hasConcept C2780640218 @default.
- W4317042446 hasConcept C2780775167 @default.
- W4317042446 hasConcept C2781137167 @default.
- W4317042446 hasConcept C42219234 @default.
- W4317042446 hasConcept C71924100 @default.
- W4317042446 hasConceptScore W4317042446C118552586 @default.
- W4317042446 hasConceptScore W4317042446C126322002 @default.
- W4317042446 hasConceptScore W4317042446C141071460 @default.
- W4317042446 hasConceptScore W4317042446C168563851 @default.
- W4317042446 hasConceptScore W4317042446C187212893 @default.
- W4317042446 hasConceptScore W4317042446C204243189 @default.
- W4317042446 hasConceptScore W4317042446C2776572573 @default.
- W4317042446 hasConceptScore W4317042446C2777704947 @default.
- W4317042446 hasConceptScore W4317042446C2778534260 @default.
- W4317042446 hasConceptScore W4317042446C2780372218 @default.
- W4317042446 hasConceptScore W4317042446C2780640218 @default.
- W4317042446 hasConceptScore W4317042446C2780775167 @default.
- W4317042446 hasConceptScore W4317042446C2781137167 @default.
- W4317042446 hasConceptScore W4317042446C42219234 @default.
- W4317042446 hasConceptScore W4317042446C71924100 @default.
- W4317042446 hasLocation W43170424461 @default.
- W4317042446 hasLocation W43170424462 @default.
- W4317042446 hasOpenAccess W4317042446 @default.
- W4317042446 hasPrimaryLocation W43170424461 @default.
- W4317042446 hasRelatedWork W1968845024 @default.
- W4317042446 hasRelatedWork W1988332971 @default.
- W4317042446 hasRelatedWork W2050001262 @default.
- W4317042446 hasRelatedWork W2082531970 @default.
- W4317042446 hasRelatedWork W2087007356 @default.
- W4317042446 hasRelatedWork W2289159721 @default.
- W4317042446 hasRelatedWork W2505934928 @default.
- W4317042446 hasRelatedWork W2731771972 @default.
- W4317042446 hasRelatedWork W2902859681 @default.
- W4317042446 hasRelatedWork W3213908047 @default.
- W4317042446 isParatext "false" @default.
- W4317042446 isRetracted "false" @default.
- W4317042446 workType "article" @default.