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- W4317181605 abstract "Background and aims Ingested inorganic arsenic (iAs) is a human carcinogen that is also linked to other adverse health effects, such as respiratory outcomes. Yet, among populations consuming low-arsenic drinking water, the impact of iAs exposure on childhood respiratory health is still uncertain. Here, it is investigated the association between iAs exposure and respiratory outcomes assessed at 4 and 7 years of age in children living in Spain. In Spain, low-arsenic drinking water is usually available and ingestion of iAs from food is considered the major source of exposure. Methods Our study population of 400 children come from the INMA cohort study (INfancia y Medio Ambiente). The summation of 4-year-old children’s urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) was used as a biomarker of iAs exposure (∑As) (median of 4.92 µg/L). Children’s occurrence of asthma, eczema, sneeze, wheeze, and medication for asthma and wheeze at each assessment time point (i.e., 4- and 7-year) was assessed with maternal interviewer-led questionnaires. Crude and adjusted Poisson regression models using Generalized Estimating Equation (GEE) were performed to account for the association between natural logarithm transformed (ln) urinary ∑As at 4 years and repeated assessments of respiratory symptoms at 4 and 7 years of age adjusting for covariates. Results The GEE - splines function using Poisson regression showed an increased trend of the overall expected counts of respiratory symptoms with urinary ∑As. The adjusted expected counts (95% confidence intervals) at ln-transformed urinary ∑As 1.57 (average concentration) and 4.00 (99th percentile) were 0.63 (0.36, 1.10) and 1.33 (0.61, 2.89), respectively. Conclusions These findings suggest that even relatively low-iAs exposure levels, relevant to the Spanish and other populations, may relate to an increased number of respiratory symptoms during childhood. Keywords Respiratory outcomes; Urinary arsenic speciation; Children; Inorganic arsenic." @default.
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- W4317181605 date "2022-09-18" @default.
- W4317181605 modified "2023-10-17" @default.
- W4317181605 title "Arsenic exposure and respiratory outcomes during childhood in the INMA study" @default.
- W4317181605 doi "https://doi.org/10.1289/isee.2022.p-0461" @default.
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