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- W4317181720 abstract "Background and Aim: Para-dichlorobenzene (p-DCB) is a volatile compound commonly used as pest repellent and air deodorant in the home and public buildings. There has been an increasing concern about its metabolic and endocrine effects. The aim of the present study was to explore the relation between p-DCB exposure and serum levels of soluble α-Klotho, an anti-aging hormone, in US adults. Methods: A nationally representative subsample of 1485 adults 40-79 ages in the 2013-2016 National Health and Nutrition Examination Survey was analyzed for the association between urinary concentrations of 2,5-dichlorophenol (2,5-DCP), the major metabolite of p-DCB, and serum α-Klotho levels using multiple general linear models, adjusting for potential confounders. Age- and sex-specific analyses were further conducted. Results: The weighted geometric mean of urinary 2,5-DCP was 2.43 µg/L and the weighted mean of serum α-Klotho was 831.97 pg/mL in the study participants during 2013-2016. After adjusting for potential confounders, urinary 2,5-DCP was significantly associated with decreased serum levels of α-Klotho (regression coefficient β=-9.88; p=0.0133) in the total study population. When age- and sex-specific analyses being conducted, a significantly inverse association was found in older adults aged 60-79 years (β=-20.52; p<0.0001) and in males (β=-13.81; p=0.0097), but not in the middle ages (40-59 years) and in females. The strongest association was observed in older (60-79 years) male participants, with a 25.25 pg/mL reduction of α-Klotho levels per 1-unit increase of 2,5-DCP concentrations (p=0.0007). No statistically significant associations with α-Klotho levels were observed for urinary 2,4-dichlorophenol, another dichlorophenol pesticide. Conclusions: Our study demonstrates a relation between p-DCB exposure, measured as 2,5-DCP, and decreased α-Klotho levels in older men. Additional studies would further explore these interactions and elucidate the pathogenesis of the potential effects of p-DCB exposure on aging. Keywords: 2,5-dichlorophenol, α-Klotho; middle and late adulthood, NHANES; para-dichlorobenzene exposure" @default.
- W4317181720 created "2023-01-18" @default.
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- W4317181720 date "2022-09-18" @default.
- W4317181720 modified "2023-10-16" @default.
- W4317181720 title "Para-dichlorobenzene exposure and serum α-Klotho levels among US participants in their middle and late adulthood" @default.
- W4317181720 doi "https://doi.org/10.1289/isee.2022.p-0047" @default.
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