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- W4317181840 abstract "BACKGROUND AND AIM: There is limited understanding of the effects of lead (Pb) on endocrine health, specifically thyroid function. Our study aimed to identify the relationship between blood Pb levels (BLLs) of the Serbian population and thyroid hormone levels and to determine a benchmark dose (BMD). METHODS: The study included 435 participants, 218 females, and 217 males. BLLs and levels of free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) in were measured. Multivariate linear regression analyses of BLLs (Pb µg/dL) and levels of hormones were performed. Further, BMD-response modelling for tested endpoints using PROAST70.1 software was performed, where hormone levels were coded as quantal data (0–in normal range and 1–out of normal range). RESULTS: Male BLLs (β = -0.01, P = 0.0281) and overall BLLs (β = -0.0041, P = 0.0143) were negatively correlated with fT4 levels, but no correlation was found in the female group. Dose-response modelling showed a positive incidence of abnormal hormone levels. For TSH, related BMDLs were 0.702 μg/dL for males and 0.686 μg/dL for females. In males, derived BMDL was 0.268 μg/dL and in females, 1.8 μg/dL for fT3. In case of fT4, derived BMDLs were 0.736 μg/dL and 0.478 μg/dL in males and females, respectively. CONCLUSIONS: The presented results suggest that Pb acts as a thyroid hormone disruptor in males. BMD modelling has shown a clear dose-response relationship with a positive trend between BLLs and levels of TSH, fT3 and fT4. The observed BMDLs were lower than median BLLs. In males, the lowest BMD was derived for fT3 (0.268 µg/dL), while in females, the lowest BMD was for fT4 (0.478 µg/dL), providing new insight into assessing human health risk assessment of low Pb exposure, especially with regards to its endocrine-disrupting effects. (PROMIS DecodExpo project: 6066532) Keywords: BLL, BMD, Human data, Endocrine disruptor" @default.
- W4317181840 created "2023-01-18" @default.
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- W4317181840 date "2022-09-18" @default.
- W4317181840 modified "2023-09-27" @default.
- W4317181840 title "Benchmark dose modelling of blood lead levels and thyroid hormones – Study in Serbian population" @default.
- W4317181840 doi "https://doi.org/10.1289/isee.2022.p-0799" @default.
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