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- W4317182252 abstract "Background and Aim Worldwide, about 2 billion people use biomass fuels for home heating and cooking. In low- and middle-income countries, wood is often burned in open hearths or inefficient stoves, exposing people to hazardous pollutants. Over 2 million U.S. households use wood as their primary source of heating. In the U.S., wood is often perceived as safe because it is a natural substance. To inform a cancer hazard evaluation for possible listing of wood smoke in the Report on Carcinogens, we conducted a systematic review and meta-analysis of studies of wood use and lung cancer. Methods We searched three bibliographic databases for studies of wood smoke exposure and lung cancer and selected studies providing risk estimates explicitly for wood use. Using a structured protocol, we evaluated study informativeness (risk of bias and study sensitivity) and pooled the least biased, most relevant risk estimates from each study, employing random-effect models to calculate meta-ORs. Results Of the ten studies meeting our inclusion criteria, two-thirds were informative based on study evaluation guidelines. All queried wood use for fuel, potentially leading to non-differential exposure misclassification as fuel may be an imperfect surrogate for wood smoke levels. Most studies addressed the major potential confounders (e.g., smoking, socioeconomic status, [SES]/education); however, in some studies, it was unclear if wood users also used coal. Residual confounding by SES is also possible. The meta-ORs and 95% confidence intervals for using wood as fuel were 1.49 (1.22–1.82) for all studies, 1.35 (1.16–1.58) for never smokers, and 1.39 (1.21–1.58) for women. The meta-OR for informative studies was higher than that for less informative studies. Never smoker studies were the least consistent. Conclusions Globally, wood smoke was associated with lung cancer risk and robust in subgroup analyses. Additional analyses are ongoing. Keywords Wood smoke, lung cancer, meta-analysis, systematic review" @default.
- W4317182252 created "2023-01-18" @default.
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- W4317182252 date "2022-09-18" @default.
- W4317182252 modified "2023-10-16" @default.
- W4317182252 title "Systematic review and meta-analysis of studies of exposure to wood smoke from cooking or heating and lung cancer" @default.
- W4317182252 doi "https://doi.org/10.1289/isee.2022.p-1051" @default.
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