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• W4317182303 abstract "BACKGROUND/AIM Globally, 3 billion people rely on solid fuels for cooking and heating, which generates household air pollution (HAP), contributing to preventable morbidity and mortality. The Household Air Pollution Intervention Network (HAPIN) trial was designed to assess the effect of a liquid petroleum gas (LPG) stove intervention on HAP exposure and maternal-child health outcomes. We conducted a sub-study to explore the breastmilk metabolomes among women in the rural Guatemala HAPIN site. METHODS Participants were excluded if they delivered by cesarean section, did not intend to breastfeed, or experienced mastitis or antibiotic use in the previous 48-hours. Breastmilk samples were collected from 75 women at six months postpartum using a standardized protocol, transported on dry ice, and processed using high-resolution mass spectrometry. Metabolic features were enhanced, and batch corrected with high quality control methods. Annotated features were quantile normalized, log transformed and analyzed using MetaboAnalyst 5.0. RESULTS Thirty-eight breastmilk samples were collected from women in the LPG intervention arm; 37 samples were collected from women in the control arm exposed to solid biomass fuels. The two-sample t-test with equal variances identified 262 significant features with one remaining significant after controlling for the false discovery rate. The fold change analysis (threshold of 2.0) revealed twenty-five up-regulated and four down-regulated features in the LPG group, compared to control (p&#x3c;0.05). Pathway enrichment analysis identified significant pathway disruption in the carnitine shuttle, arginine and proline metabolism, aminosugar metabolism and lysine metabolism when comparing breastmilk from participants using LPG versus solid biomass (all p&#x3c;0.05). CONCLUSIONS Minimal significant features were identified among breastmilk samples from participants in the study based on study arm assignment, but several variations were seen among metabolic pathways. Further exploration of maternal nutrition in concurrence with environmental exposures may provide additional differences in the breastmilk metabolome. KEYWORDS Metabolomics, Nutrition, Breastmilk, Air Pollutants, Exposure" @default.
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• W4317182303 date "2022-09-18" @default.
• W4317182303 modified "2023-09-30" @default.
• W4317182303 title "Untargeted metabolomics analysis of human milk samples from Guatemalan mothers in the Household Air Pollution Intervention Network (HAPIN) Trial" @default.
• W4317182303 doi "https://doi.org/10.1289/isee.2022.p-0136" @default.
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