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- W4317182328 abstract "Background and aim: Endocrine disrupting chemicals (EDCs) can interfere with the hormone action and are able to cross the placenta and thereby expose the foetus. If the foetus is exposed, it can have an effect on the development of the nervous system with neurobehavioral consequences. Thus, the aim of this study is to estimate the association between prenatal exposure to EDCs and neurobehaviour in children. Methods: Based on the pregnancy cohort Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy (SELMA) study, 700 mother-child pairs were selected to estimate associations between prenatal exposure to EDCs and neurobehavioural outcomes using the Strengths and Difficulties Questionnaire (SDQ). Associations were estimated for the total SDQ score and a 90th percentile cut-off to identify cases that might be of clinical importance. Linear, logistic and weighted quantile sum (WQS) regressions were used to estimate betas (β), odds ratios (ORs) and 95% confidence intervals (95% CI). The models were adjusted for urinary creatinine concentration, mother’s education, smoking status, age and parity and child’s sex and age at outcome assessment. Results: Prenatal levels of MBzP (methylbenzylphthalate) measured in the pregnant mothers’ urine were found to be associated with significantly higher SDQ scores (more problems) in adjusted analyses: linear regressions (β 1.49, 95% CI 0.64-2.33) and logistic regression (OR 1.95, 95% CI 1.03-3.70). Further, MBzP was the chemical with the highest weight in the adjusted mixture analyses (WQS), in both the linear (β 0.49, 95% CI 0.22-0.75) and logistic regression (ORs 1.35, 95% CI 1.10-1.64). There were no sex differences in any of the analyses. Conclusions: MBzP, a phthalate used in vinyl flooring and adhesives, seems to be a chemical of concern when assessing indicators for neurobehavioural outcomes in children. Further studies are needed to explain a possible biological mechanism behind these findings. Keywords: Endocrine disrupting chemicals, neurobehaviour" @default.
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- W4317182328 date "2022-09-18" @default.
- W4317182328 modified "2023-10-16" @default.
- W4317182328 title "Prenatal exposure to endocrine disrupting chemicals and the association to behavioural outcomes in children at age seven in the SELMA study" @default.
- W4317182328 doi "https://doi.org/10.1289/isee.2022.o-op-248" @default.
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