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- W4317193662 abstract "The symposium discussed mechanisms of interleukin (IL)-6 blockade for the treatment and management of patients with rheumatoid arthritis (RA). Prof Smolen provided a clinical update of the latest efficacy and safety data on various anti-IL-6 drugs, including sirukumab. He noted that all anti-IL-6 drugs were efficacious in treating physical and mental symptoms of RA. When the efficacy of anti-IL-6 antibodies was compared between drugs, targeting the IL-6 ligand was similar to targeting its receptor. Prof Pitzalis described the pathophysiology of IL-6 in RA and the reason for targeting IL-6. Lastly, Prof Choy outlined the importance of measuring patient-reported outcomes to monitor symptom improvement and evaluate the impact of IL-6 on mental functioning. Because IL-6 modulates the hypothalamic pituitary axis, fatigue and depression are common in patients with RA. Evidence suggests that the inhibition of IL-6 activity reduces symptoms of fatigue and depression in patients with RA, and that improvement in mental health occurs independently, rather than as a consequence of improvement in physical functioning." @default.
- W4317193662 created "2023-01-18" @default.
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- W4317193662 date "2017-12-01" @default.
- W4317193662 modified "2023-09-27" @default.
- W4317193662 title "Considering Patients’ Needs: Action and Reaction of Interleukin-6 Blockade" @default.
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- W4317193662 doi "https://doi.org/10.33590/emjrheumatol/10312838" @default.
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