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- W4317207032 endingPage "52" @default.
- W4317207032 startingPage "52" @default.
- W4317207032 abstract "Damage to intervertebral discs (IVD) can lead to chronic pain and disability, and no current treatments can fully restore their function. Some non-surgical treatments have shown promise; however, these approaches are generally limited by burst release and poor localization of diverse molecules. In this proof-of-concept study, we developed a nanoparticle (NP) delivery system to efficiently deliver high- and low-solubility drug molecules. Nanoparticles of cellulose acetate and polycaprolactone-polyethylene glycol conjugated with 1-oxo-1H-pyrido [2,1-b][1,3]benzoxazole-3-carboxylic acid (PBC), a novel fluorescent dye, were prepared by the oil-in-water emulsion. Two drugs, a water insoluble indomethacin (IND) and a water soluble 4-aminopyridine (4-AP), were used to study their release patterns. Electron microscopy confirmed the spherical nature and rough surface of nanoparticles. The particle size analysis revealed a hydrodynamic radius ranging ~150-162 nm based on dynamic light scattering. Zeta potential increased with PBC conjugation implying their enhanced stability. IND encapsulation efficiency was almost 3-fold higher than 4-AP, with release lasting up to 4 days, signifying enhanced solubility, while the release of 4-AP continued for up to 7 days. Nanoparticles and their drug formulations did not show any apparent cytotoxicity and were taken up by human IVD nucleus pulposus cells. When injected into coccygeal mouse IVDs in vivo, the nanoparticles remained within the nucleus pulposus cells and the injection site of the nucleus pulposus and annulus fibrosus of the IVD. These fluorescent nano-formulations may serve as a platform technology to deliver therapeutic agents to IVDs and other tissues that require localized drug injections." @default.
- W4317207032 created "2023-01-18" @default.
- W4317207032 creator A5003519315 @default.
- W4317207032 creator A5004375970 @default.
- W4317207032 creator A5015090356 @default.
- W4317207032 creator A5027089478 @default.
- W4317207032 creator A5041084960 @default.
- W4317207032 creator A5042237038 @default.
- W4317207032 creator A5062658027 @default.
- W4317207032 creator A5089377894 @default.
- W4317207032 date "2023-01-17" @default.
- W4317207032 modified "2023-10-16" @default.
- W4317207032 title "Novel Injectable Fluorescent Polymeric Nanocarriers for Intervertebral Disc Application" @default.
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- W4317207032 doi "https://doi.org/10.3390/jfb14020052" @default.
- W4317207032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36826851" @default.
- W4317207032 hasPublicationYear "2023" @default.