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- W4317207906 abstract "Abstract Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality. The vaginal microbiome has been associated with PTB, yet the mechanisms underlying this association are not fully understood. Understanding microbial genetic adaptations to selective pressures, especially those related to the host, may yield new insights into these associations. To this end, we analyzed metagenomic data from 705 vaginal samples collected longitudinally during pregnancy from 40 women who delivered preterm spontaneously and 135 term controls from the Multi-Omic Microbiome Study-Pregnancy Initiative (MOMS-PI 1 ). We find that the vaginal microbiome of pregnancies that ended preterm exhibits unique genetic profiles. It is more genetically diverse at the species level, a result which we validate in an additional cohort, and harbors a higher richness and diversity of antimicrobial resistance genes, likely promoted by transduction. Interestingly, we find that Gardnerella species, a group of central vaginal pathobionts, are driving this higher genetic diversity, particularly during the first half of the pregnancy. We further present evidence that Gardnerella spp. undergoes more frequent recombination and stronger purifying selection in genes involved in lipid metabolism. Overall, our results reveal novel associations between the vaginal microbiome and PTB using population genetics analyses, and suggest that evolutionary processes acting on the vaginal microbiome may play a vital role in adverse pregnancy outcomes such as preterm birth." @default.
- W4317207906 created "2023-01-18" @default.
- W4317207906 creator A5006465082 @default.
- W4317207906 creator A5010801631 @default.
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- W4317207906 creator A5045328383 @default.
- W4317207906 creator A5051290724 @default.
- W4317207906 creator A5070875326 @default.
- W4317207906 date "2023-01-17" @default.
- W4317207906 modified "2023-10-17" @default.
- W4317207906 title "Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth" @default.
- W4317207906 cites W1512841246 @default.
- W4317207906 cites W1831022746 @default.
- W4317207906 cites W1850249898 @default.
- W4317207906 cites W1899317453 @default.
- W4317207906 cites W1930591173 @default.
- W4317207906 cites W1965499878 @default.
- W4317207906 cites W1973965874 @default.
- W4317207906 cites W1975755498 @default.
- W4317207906 cites W2013371150 @default.
- W4317207906 cites W2021699663 @default.
- W4317207906 cites W2023566940 @default.
- W4317207906 cites W2045641296 @default.
- W4317207906 cites W2063756198 @default.
- W4317207906 cites W2067066152 @default.
- W4317207906 cites W2067713285 @default.
- W4317207906 cites W2074974657 @default.
- W4317207906 cites W2093917326 @default.
- W4317207906 cites W2110065044 @default.
- W4317207906 cites W2112364185 @default.
- W4317207906 cites W2129233971 @default.
- W4317207906 cites W2130597146 @default.
- W4317207906 cites W2131271579 @default.
- W4317207906 cites W2133790733 @default.
- W4317207906 cites W2139134537 @default.
- W4317207906 cites W2141052558 @default.
- W4317207906 cites W2141137078 @default.
- W4317207906 cites W2143485490 @default.
- W4317207906 cites W2144109968 @default.
- W4317207906 cites W2147108540 @default.
- W4317207906 cites W2150291618 @default.
- W4317207906 cites W2151372451 @default.
- W4317207906 cites W2170551349 @default.
- W4317207906 cites W2316101429 @default.
- W4317207906 cites W2323475624 @default.
- W4317207906 cites W2586260025 @default.
- W4317207906 cites W2599417231 @default.
- W4317207906 cites W2618482548 @default.
- W4317207906 cites W2621775596 @default.
- W4317207906 cites W2623963207 @default.
- W4317207906 cites W2736920791 @default.
- W4317207906 cites W2749873900 @default.
- W4317207906 cites W2769676847 @default.
- W4317207906 cites W2782680734 @default.
- W4317207906 cites W2797563686 @default.
- W4317207906 cites W2803574693 @default.
- W4317207906 cites W2803721377 @default.
- W4317207906 cites W2810934340 @default.
- W4317207906 cites W2900629010 @default.
- W4317207906 cites W2911005883 @default.
- W4317207906 cites W2924485771 @default.
- W4317207906 cites W2938868597 @default.
- W4317207906 cites W2941703063 @default.
- W4317207906 cites W2947640277 @default.
- W4317207906 cites W2950155065 @default.
- W4317207906 cites W2952218813 @default.
- W4317207906 cites W2952492514 @default.
- W4317207906 cites W2972722913 @default.
- W4317207906 cites W2973794265 @default.
- W4317207906 cites W2977541623 @default.
- W4317207906 cites W2981900702 @default.
- W4317207906 cites W2982531601 @default.
- W4317207906 cites W2986925300 @default.
- W4317207906 cites W2990248540 @default.
- W4317207906 cites W2999728398 @default.
- W4317207906 cites W3015471407 @default.
- W4317207906 cites W3033628182 @default.
- W4317207906 cites W3036934263 @default.
- W4317207906 cites W3037946591 @default.
- W4317207906 cites W3044048669 @default.
- W4317207906 cites W3045922833 @default.
- W4317207906 cites W3081657721 @default.
- W4317207906 cites W3084081494 @default.
- W4317207906 cites W3088258077 @default.
- W4317207906 cites W3090089243 @default.
- W4317207906 cites W3095462271 @default.
- W4317207906 cites W3096441012 @default.
- W4317207906 cites W3098348207 @default.
- W4317207906 cites W3108785720 @default.
- W4317207906 cites W3122118092 @default.
- W4317207906 cites W3131055609 @default.
- W4317207906 cites W3131565611 @default.
- W4317207906 cites W3135930237 @default.
- W4317207906 cites W3156458251 @default.
- W4317207906 cites W3159167168 @default.
- W4317207906 cites W3160235274 @default.
- W4317207906 cites W3172516310 @default.
- W4317207906 cites W3177018090 @default.
- W4317207906 cites W3181235930 @default.
- W4317207906 cites W3188729616 @default.