Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317214919> ?p ?o ?g. }
- W4317214919 endingPage "135" @default.
- W4317214919 startingPage "125" @default.
- W4317214919 abstract "Interaction scaffolds that selectively recognize disordered protein strongly shape protein interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N-terminal domain (TND). The TND is a five-helical bundle that has no known enzymatic activity, but instead selectively reads intrinsically disordered sequences of other proteins. Here, we review the structural and functional properties of TNDs and their cognate disordered ligands known as TND-interacting motifs (TIMs). TNDs or TIMs are found in prominent members of the transcription machinery, including TFIIS, super elongation complex, SWI/SNF, Mediator, IWS1, SPT6, PP1-PNUTS phosphatase, elongin, H3K36me3 readers, the transcription factor MYC, and others. We also review how the TND interactome contributes to the regulation of transcription. Because the TND is the most significantly enriched fold among transcription elongation regulators, TND- and TIM-driven interactions have widespread roles in the regulation of many transcriptional processes." @default.
- W4317214919 created "2023-01-18" @default.
- W4317214919 creator A5001413826 @default.
- W4317214919 creator A5038916070 @default.
- W4317214919 creator A5076517869 @default.
- W4317214919 date "2023-01-18" @default.
- W4317214919 modified "2023-10-02" @default.
- W4317214919 title "The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder" @default.
- W4317214919 cites W102715436 @default.
- W4317214919 cites W130301589 @default.
- W4317214919 cites W1596462402 @default.
- W4317214919 cites W1851343525 @default.
- W4317214919 cites W1863439705 @default.
- W4317214919 cites W1967615956 @default.
- W4317214919 cites W1968153105 @default.
- W4317214919 cites W1975150670 @default.
- W4317214919 cites W1980365766 @default.
- W4317214919 cites W1981493445 @default.
- W4317214919 cites W1984901090 @default.
- W4317214919 cites W1985711767 @default.
- W4317214919 cites W1985719370 @default.
- W4317214919 cites W1992983658 @default.
- W4317214919 cites W2008809596 @default.
- W4317214919 cites W2023149772 @default.
- W4317214919 cites W2038045924 @default.
- W4317214919 cites W2039091977 @default.
- W4317214919 cites W2043677605 @default.
- W4317214919 cites W2044793296 @default.
- W4317214919 cites W2054261736 @default.
- W4317214919 cites W2055467185 @default.
- W4317214919 cites W2058074152 @default.
- W4317214919 cites W2083292764 @default.
- W4317214919 cites W2083387716 @default.
- W4317214919 cites W2087377128 @default.
- W4317214919 cites W2094799740 @default.
- W4317214919 cites W2095346103 @default.
- W4317214919 cites W2096275987 @default.
- W4317214919 cites W2098741254 @default.
- W4317214919 cites W2101359917 @default.
- W4317214919 cites W2146093012 @default.
- W4317214919 cites W2150608129 @default.
- W4317214919 cites W2169340453 @default.
- W4317214919 cites W2310066925 @default.
- W4317214919 cites W2344518204 @default.
- W4317214919 cites W2410596301 @default.
- W4317214919 cites W2528982417 @default.
- W4317214919 cites W2535071049 @default.
- W4317214919 cites W2552001782 @default.
- W4317214919 cites W2585951574 @default.
- W4317214919 cites W2601670548 @default.
- W4317214919 cites W2612611322 @default.
- W4317214919 cites W2621819549 @default.
- W4317214919 cites W2660877075 @default.
- W4317214919 cites W2744956717 @default.
- W4317214919 cites W2752525798 @default.
- W4317214919 cites W2808119477 @default.
- W4317214919 cites W2809057270 @default.
- W4317214919 cites W2835153656 @default.
- W4317214919 cites W2886356771 @default.
- W4317214919 cites W2888154852 @default.
- W4317214919 cites W2888537731 @default.
- W4317214919 cites W2895067602 @default.
- W4317214919 cites W2914140608 @default.
- W4317214919 cites W2967566569 @default.
- W4317214919 cites W2977894246 @default.
- W4317214919 cites W2982494755 @default.
- W4317214919 cites W2982561006 @default.
- W4317214919 cites W2988357750 @default.
- W4317214919 cites W2990219485 @default.
- W4317214919 cites W2994082096 @default.
- W4317214919 cites W2997966709 @default.
- W4317214919 cites W3003540174 @default.
- W4317214919 cites W3010823740 @default.
- W4317214919 cites W3017706363 @default.
- W4317214919 cites W3030695012 @default.
- W4317214919 cites W3087455301 @default.
- W4317214919 cites W3087521592 @default.
- W4317214919 cites W3089235055 @default.
- W4317214919 cites W3092921638 @default.
- W4317214919 cites W3108458932 @default.
- W4317214919 cites W3111174503 @default.
- W4317214919 cites W3119680461 @default.
- W4317214919 cites W3121637965 @default.
- W4317214919 cites W3122647193 @default.
- W4317214919 cites W3135623882 @default.
- W4317214919 cites W3143867892 @default.
- W4317214919 cites W3161698207 @default.
- W4317214919 cites W3199141941 @default.
- W4317214919 cites W3217393517 @default.
- W4317214919 cites W4205379795 @default.
- W4317214919 cites W4213190051 @default.
- W4317214919 cites W4214492388 @default.
- W4317214919 cites W4220868903 @default.
- W4317214919 cites W4280608758 @default.
- W4317214919 cites W4282959256 @default.
- W4317214919 cites W4286257123 @default.
- W4317214919 cites W4293068298 @default.
- W4317214919 cites W4308616064 @default.