FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317215087> ?p ?o ?g. }

• W4317215087 abstract "The cGAS-STING signaling pathway can trigger innate immune responses by detecting dsDNA from outside or within the host. In addition, the cGAS-STING signaling pathway has emerged as a critical mediator of the inflammatory response and a new target for inflammatory diseases. STING activation leads to dimerization and translocation to the endoplasmic reticulum Golgi intermediate compartment or Golgi apparatus catalyzed by TBK1, triggers the production of IRF3 and NF-κB and translocates to the nucleus to induce a subsequent interferon response and pro-inflammatory factor production. Osteoporosis is a degenerative bone metabolic disease accompanied by chronic sterile inflammation. Activating the STING/IFN-β signaling pathway can reduce bone resorption by inhibiting osteoclast differentiation. Conversely, activation of STING/NF-κB leads to the formation of osteoporosis by increasing bone resorption and decreasing bone formation. In addition, activation of STING inhibits the generation of type H vessels with the capacity to osteogenesis, thereby inhibiting bone formation. Here, we outline the mechanism of action of STING and its downstream in osteoporosis and discuss the role of targeting STING in the treatment of osteoporosis, thus providing new ideas for the treatment of osteoporosis." @default.
• W4317215087 created "2023-01-18" @default.
• W4317215087 creator A5000849957 @default.
• W4317215087 creator A5031191384 @default.
• W4317215087 creator A5041987269 @default.
• W4317215087 creator A5049341927 @default.
• W4317215087 creator A5063902702 @default.
• W4317215087 creator A5083874700 @default.
• W4317215087 date "2023-01-18" @default.
• W4317215087 modified "2023-10-18" @default.
• W4317215087 title "Targeting STING: From antiviral immunity to treat osteoporosis" @default.
• W4317215087 cites W1524557269 @default.
• W4317215087 cites W1549046020 @default.
• W4317215087 cites W1822745879 @default.
• W4317215087 cites W1898887656 @default.
• W4317215087 cites W1904752902 @default.
• W4317215087 cites W1965404141 @default.
• W4317215087 cites W1966923590 @default.
• W4317215087 cites W1967291007 @default.
• W4317215087 cites W1967311860 @default.
• W4317215087 cites W1967937835 @default.
• W4317215087 cites W1972082473 @default.
• W4317215087 cites W1972285445 @default.
• W4317215087 cites W1975953388 @default.
• W4317215087 cites W1976216407 @default.
• W4317215087 cites W1976382352 @default.
• W4317215087 cites W1977753585 @default.
• W4317215087 cites W1977830503 @default.
• W4317215087 cites W1981477005 @default.
• W4317215087 cites W1985178819 @default.
• W4317215087 cites W1985891126 @default.
• W4317215087 cites W1986208864 @default.
• W4317215087 cites W1991762596 @default.
• W4317215087 cites W1993990835 @default.
• W4317215087 cites W1998877652 @default.
• W4317215087 cites W2000038050 @default.
• W4317215087 cites W2003213153 @default.
• W4317215087 cites W2004316687 @default.
• W4317215087 cites W2005821352 @default.
• W4317215087 cites W2013818100 @default.
• W4317215087 cites W2014225480 @default.
• W4317215087 cites W2014860274 @default.
• W4317215087 cites W2015310325 @default.
• W4317215087 cites W2015329065 @default.
• W4317215087 cites W2016531821 @default.
• W4317215087 cites W2023016113 @default.
• W4317215087 cites W2027365426 @default.
• W4317215087 cites W2027496373 @default.
• W4317215087 cites W2031157573 @default.
• W4317215087 cites W2038466746 @default.
• W4317215087 cites W2041345682 @default.
• W4317215087 cites W2042391178 @default.
• W4317215087 cites W2043136359 @default.
• W4317215087 cites W2045705524 @default.
• W4317215087 cites W2049620083 @default.
• W4317215087 cites W2050724276 @default.
• W4317215087 cites W2052313621 @default.
• W4317215087 cites W2053490208 @default.
• W4317215087 cites W2055590859 @default.
• W4317215087 cites W2060004514 @default.
• W4317215087 cites W2062390774 @default.
• W4317215087 cites W2063595818 @default.
• W4317215087 cites W2063702713 @default.
• W4317215087 cites W2064346787 @default.
• W4317215087 cites W2066574904 @default.
• W4317215087 cites W2066818317 @default.
• W4317215087 cites W2072473099 @default.
• W4317215087 cites W2074255445 @default.
• W4317215087 cites W2075225271 @default.
• W4317215087 cites W2079819700 @default.
• W4317215087 cites W2085016903 @default.
• W4317215087 cites W2089254126 @default.
• W4317215087 cites W2091129202 @default.
• W4317215087 cites W2093252878 @default.
• W4317215087 cites W2094863064 @default.
• W4317215087 cites W2097750604 @default.
• W4317215087 cites W2101328621 @default.
• W4317215087 cites W2103133890 @default.
• W4317215087 cites W2106877484 @default.
• W4317215087 cites W2111948424 @default.
• W4317215087 cites W2122367477 @default.
• W4317215087 cites W2124451653 @default.
• W4317215087 cites W2127200072 @default.
• W4317215087 cites W2135919238 @default.
• W4317215087 cites W2140813939 @default.
• W4317215087 cites W2144259303 @default.
• W4317215087 cites W2150240428 @default.
• W4317215087 cites W2153865301 @default.
• W4317215087 cites W2155214429 @default.
• W4317215087 cites W2159979956 @default.
• W4317215087 cites W2160832259 @default.
• W4317215087 cites W2161901483 @default.
• W4317215087 cites W2166266977 @default.
• W4317215087 cites W2173816666 @default.
• W4317215087 cites W2217821029 @default.
• W4317215087 cites W2256879069 @default.
• W4317215087 cites W2276240424 @default.
• W4317215087 cites W2304363596 @default.
• W4317215087 cites W2328714619 @default.
• W4317215087 cites W2342838007 @default.

• next