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- W4317233414 abstract "In this work, a symmetrical metalloporphyrin with copper as the center and four carboxyphenyl around was synthesized by two-step hydrothermal method. Subsequently, the polymerization of Cu-TCPP (Copper-centered tetrakis (4-carboxyphenyl) porphyrin) on GCE was achieved by a low-cost and simple electrochemical method. The introduction of copper improved the biocompatibility, electrocatalytic activity, and conductivity of porphyrins. At the same time, the large conjugation structure of the porphyrins increases the electron transfer rate and amplifies the current signal. The introduction of copper and the planar conjugate structure complement each other, resulting in higher sensitivity and stability of the novel sensor. Under optimal conditions, the biosensor can detect guanine (G), adenine (A), thymine (T) and cytosine (C) simultaneously and accurately. (The peak potentials are 0.677, 0.975, 1.140 and 1.313 V, respectively.) The poly(Cu-TCPP)/GCE biosensor also has a good linear response to G, A, T and C in the concentration range of 5–400, 5–300, 20–700 and 10–700 μM, respectively. To sum up, a new electrochemical sensor has been successfully constructed that has the potential to be used to detect some diseases early." @default.
- W4317233414 created "2023-01-18" @default.
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- W4317233414 date "2023-02-01" @default.
- W4317233414 modified "2023-10-12" @default.
- W4317233414 title "A novel handy polymerized copper porphyrin sensor detects bases simultaneously" @default.
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- W4317233414 doi "https://doi.org/10.1016/j.jelechem.2023.117171" @default.
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