Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317233762> ?p ?o ?g. }
- W4317233762 endingPage "27" @default.
- W4317233762 startingPage "1" @default.
- W4317233762 abstract "Tracks rich in matrix and cells, as described in several cancer types, have immunosuppressive functions and separate tumor nests and stroma, yet their origin is unknown. Immunostainings of cryosections from mouse breast tumors show that these tracks are bordered by an endothelial-like basement membrane, filled with fibers of collagen adjacent to tenascin-C (TNC) and low-tension fibronectin (Fn) fibers. While present in early-stage tumors and maturing with time, tracks still form under TNC KO conditions, however, host (not tumor cell)-derived TNC is important for track maturation. Tumor infiltrating leukocytes (mostly M2 macrophages and CD8+ T cells) are retained in tracks of early-stage tumors. Following track maturation, retained tumor infiltrating leukocyte (TIL) numbers get reduced and more CD8+ TIL enter the tumor nests in the absence of TNC. As these tracks are enriched with platelets and fibrinogen and have a demarcating endothelial-like basement membrane often adjacent to endothelial cells, this suggests a role of blood vessels in the formation of these tracks. The Fn fiber tension probe FnBPA5 colocalizes with TNC and immune cells in the tracks and shows decreased binding in tracks lacking TNC. Consequently, FnBPA5 can serve as probe for tumor matrix tracks that have immune suppressive properties." @default.
- W4317233762 created "2023-01-18" @default.
- W4317233762 creator A5000095939 @default.
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- W4317233762 creator A5087623059 @default.
- W4317233762 creator A5089767733 @default.
- W4317233762 date "2023-02-01" @default.
- W4317233762 modified "2023-09-26" @default.
- W4317233762 title "Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers" @default.
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