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- W4317240938 abstract "Schistosomiasis is a neglected disease in tropical and subtropical countries. Angola, despite the significant improvement of some of its global health indicators, still has a high incidence of neglected diseases like schistosomiasis. In some regions, medicinal plants are the most available or even the only treatment to this disease in rural communities. Vernonia britteniana Hiern (Asteraceae), root is one of the medicinal plants identified by us as used in Angolan traditional medicine to treat schistosomiasis. Our study aimed to evaluate the in vitro cercaricidal of two extracts (water, WE) and hydroethanolic 70%, HE70) made with this herbal medicine. Additionally, the phytochemical profile of these extracts was also accessed. The cercaricidal activity was evaluated against Schistosoma mansoni cercariae, exposed to different concentrations of each extract (500, 438, and 125 µg/ml) and observed at 30, 60, 90, 120, and 150 min. Praziquantel (10 µg/ml) was used as positive control and 1% of DMSO+water and/or deionized water as the negative control. The chromatographic profile was assessed by LC-UV-MS. Both extracts showed cercaricidal activity, with 100% cercariae mortality at 500 µg/ml after 30 min, and an LC50 of 438 μg/ml, after 120 min (p < 0.05). Chlorogenic acid, caffeic acid, 3,5-di-O-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquic acid) and vernosides A, B and D were identified for the first time in this medicinal plant and they are the main compounds of both extracts. Our results reinforce the therapeutic usefulness potential of the flora of the studied region." @default.
- W4317240938 created "2023-01-18" @default.
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- W4317240938 date "2022-12-01" @default.
- W4317240938 modified "2023-10-01" @default.
- W4317240938 title "In vitro cercaricidal activity and phytochemical profile of Vernonia britteniana root" @default.
- W4317240938 doi "https://doi.org/10.1055/s-0042-1759197" @default.
- W4317240938 hasPublicationYear "2022" @default.
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