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• W4317241400 abstract "Eremophila is a genus of approximately 230 species endemic to Australia and mainly found in the arid regions of Western Australia. Eremophila spp. have been used for medicinal and cultural purposes by the Australian Aboriginal people, and Eremophila is rich in bioactive diterpenoids and sesquiterpenoids [1], [2]. The aim of this study was to apply omics and other state-of-the-art technologies for exploring the chemical and pharmacological properties of more than 300 plant samples collected in a large interdisciplinary project and use these data to select species for further drug lead discovery. For this purpose, we used molecular phylogenetics combined with computational metabolomics to pinpoint intraspecies relationships, high-resolution inhibition profiling as a bioactivity-correlating technique, and polypharmacology-labelled molecular networking for pinpointing metabolites correlated with multiple bioactivities. The results from these explorative studies enabled us to identify Eremophila species and/or individual metabolites correlated with (poly)pharmacological bioactivity – and extracts of these species were subsequent analysed by a combination of high-resolution inhibition profiling and hyphenated high-performance liquid chromatography, photodiode-array detection, solid-phase extraction, high-resolution mass spectrometry, and nuclear magnetic resonance spectroscopy, i.e., HR-inhibition inhibition profiling/HPLC-PDA-HRMS-SPE-NMR. This resulted in isolation of more than 120 new and structurally diverse serrulatane, cembrane, and viscidane diterpenoids [3], [4] as well as a new class of dimeric branched chain fatty acids formed by Diels Alder reactions [5]. Pharmacological activities included antibacterial, antihyperglycaemic, and cancer resistance-reversing properties. In conclusion, Eremophila is a rich source of structurally unique diterpenoids with multiple bioactivities, and thus continues to be an interesting genus for natural-products-based drug discovery." @default.
• W4317241400 created "2023-01-18" @default.
• W4317241400 creator A5066539032 @default.
• W4317241400 date "2022-12-01" @default.
• W4317241400 modified "2023-09-27" @default.
• W4317241400 title "Keynote Lecture 3 “Polypharmacology-correlated Molecular Networking and other Essential Bioactivity-correlating Techniques for Studying Desert-loving Eremophila spp. from Australia”" @default.
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• W4317241400 doi "https://doi.org/10.1055/s-0042-1758905" @default.
• W4317241400 hasPublicationYear "2022" @default.
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