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- W4317241555 abstract "A crucial mechanism of multidrug resistance (MDR) of enterohaemorrhagic Escherichia coli 0157:H7 pathogenicity is its ability to form biofilms. The aim of this study was to investigate the antibacterial, anti-biofilm, anti-quorum sensing and anti-motility effects of acetone and methanol extracts of 16 plants against E. coli 0157:H7, a major foodborne pathogen. These plants were selected on the basis of preliminary antibacterial activity. Using a broth serial microdilution method, the extracts had minimum inhibitory concentration (MIC) values of 0.90 to 1.25 mg/ml. Interestingly, relatively low cytotoxicity 300<LC50 < 1000 mg/ml for all extracts against Vero cells was reported. The sub-MIC value of 0.195 mg/ml was employed for the biofilm inhibition assays. Vachellia karroo and Salix babylonica inhibited biofilm formation by approximately 70%, and V. galpinii and V. gerrardii methanol extracts were effective at eradicating a pre-formed biofilm with 93% and 77% respectively after 24 h. Several plants had good biofilm disruption ability after 48 h incubation. Anti-quorum sensing activity was studied using the biosensor strain Chromobacterium violaceum. Vachellia gerrardii acetone and methanol extracts inhibited 89% and 91% of the violacein produced respectively, indicating promising quorum sensing inhibition. Furthermore, V. gerrardii, V. nilotica and V. tortilis plant extracts showed excellent inhibition of migration of bacteria in semi-solid agar after 72 h compared to untreated bacteria. Finally, a substantial amount of biofilm extracellular polymer substance was reduced by the acetone extracts. This research provides evidence that the selected plants have good activity against biofilms caused by enterohaemorrhagic E. coli 0157:H7." @default.
- W4317241555 created "2023-01-18" @default.
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- W4317241555 date "2022-12-01" @default.
- W4317241555 modified "2023-09-27" @default.
- W4317241555 title "Short Lecture 3 “Anti-biofilm activity of sixteen South African plants against multidrug resistant E. coli 0157:H7 associated with outbreaks of diarrhoeal disease”" @default.
- W4317241555 doi "https://doi.org/10.1055/s-0042-1758894" @default.
- W4317241555 hasPublicationYear "2022" @default.
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