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- W4317349889 abstract "Introduction In recent years citalopram, a selective serotonin reuptake inhibitor, has become the focus of molecular research as a treatment for Alzheimer’s disease (AD). It has been shown that citalopram was able to lower the concentration of Aβ in the cerebrospinal fluid in humans and caused a delayed progression of Mild Cognitive Impairment to AD in patients with depression. The purpose of our study was to investigate the effects of citalopram treatment on the pathology and memory deficits in the 5xFAD mouse model of familial AD. 5xFAD mice recapitulate many AD-related phenotypes and develop an aggressive and progressive plaque pathology as well as synaptic dysfunction and neuron loss." @default.
- W4317349889 created "2023-01-19" @default.
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- W4317349889 date "2022-11-01" @default.
- W4317349889 modified "2023-09-29" @default.
- W4317349889 title "Effects of a citalopram treatment on the amyloid-β-pathology and behaviour in the 5xFAD Alzheimer mouse model" @default.
- W4317349889 doi "https://doi.org/10.1055/s-0042-1757651" @default.
- W4317349889 hasPublicationYear "2022" @default.
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