FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317360159> ?p ?o ?g. }

• W4317360159 endingPage "203" @default.
• W4317360159 startingPage "192" @default.
• W4317360159 abstract "Type IB topoisomerases relax the torsional stress associated with DNA metabolism in the nucleus and mitochondria and constitute important molecular targets of anticancer drugs. Vertebrates stand out among eukaryotes by having two Type IB topoisomerases acting specifically in the nucleus (TOP1) and mitochondria (TOP1MT). Despite their major importance, the origin and evolution of these paralogues remain unknown. Here, we examine the molecular evolutionary processes acting on both TOP1 and TOP1MT in Chordata, taking advantage of the increasing number of available genome sequences. We found that both TOP1 and TOP1MT evolved under strong purifying selection, as expected considering their essential biological functions. Critical active sites, including those associated with resistance to anticancer agents, were found particularly conserved. However, TOP1MT presented a higher rate of molecular evolution than TOP1, possibly related with its specialized activity on the mitochondrial genome and a less critical role in cells. We could place the duplication event that originated the TOP1 and TOP1MT paralogues early in the radiation of vertebrates, most likely associated with the first round of vertebrate tetraploidization (1R). Moreover, our data suggest that cyclostomes present a specialized mitochondrial Type IB topoisomerase. Interestingly, we identified two missense mutations replacing amino acids in the Linker region of TOP1MT in Neanderthals, which appears as a rare event when comparing the genome of both species. In conclusion, TOP1 and TOP1MT differ in their rates of evolution, and their evolutionary histories allowed us to better understand the evolution of chordates." @default.
• W4317360159 created "2023-01-19" @default.
• W4317360159 creator A5025731761 @default.
• W4317360159 creator A5037761662 @default.
• W4317360159 creator A5044849194 @default.
• W4317360159 creator A5089362139 @default.
• W4317360159 date "2023-01-18" @default.
• W4317360159 modified "2023-10-14" @default.
• W4317360159 title "Evolution of TOP1 and TOP1MT Topoisomerases in Chordata" @default.
• W4317360159 cites W1513087438 @default.
• W4317360159 cites W1582272319 @default.
• W4317360159 cites W1798491560 @default.
• W4317360159 cites W1963957860 @default.
• W4317360159 cites W1964961778 @default.
• W4317360159 cites W1968482171 @default.
• W4317360159 cites W1985336260 @default.
• W4317360159 cites W1994263888 @default.
• W4317360159 cites W2000628133 @default.
• W4317360159 cites W2004798786 @default.
• W4317360159 cites W2006758809 @default.
• W4317360159 cites W2009371644 @default.
• W4317360159 cites W2011223597 @default.
• W4317360159 cites W2012236088 @default.
• W4317360159 cites W2013538578 @default.
• W4317360159 cites W2018264277 @default.
• W4317360159 cites W2027956728 @default.
• W4317360159 cites W2031674105 @default.
• W4317360159 cites W2031733136 @default.
• W4317360159 cites W2033459298 @default.
• W4317360159 cites W2034699636 @default.
• W4317360159 cites W2050240034 @default.
• W4317360159 cites W2051005069 @default.
• W4317360159 cites W2057652201 @default.
• W4317360159 cites W2059390603 @default.
• W4317360159 cites W2059538856 @default.
• W4317360159 cites W2065634344 @default.
• W4317360159 cites W2067332276 @default.
• W4317360159 cites W2068134440 @default.
• W4317360159 cites W2068577449 @default.
• W4317360159 cites W2071378905 @default.
• W4317360159 cites W2115694749 @default.
• W4317360159 cites W2116335962 @default.
• W4317360159 cites W2124362779 @default.
• W4317360159 cites W2128016314 @default.
• W4317360159 cites W2130479394 @default.
• W4317360159 cites W2131871062 @default.
• W4317360159 cites W2132600317 @default.
• W4317360159 cites W2133713837 @default.
• W4317360159 cites W2135606644 @default.
• W4317360159 cites W2136847298 @default.
• W4317360159 cites W2146058063 @default.
• W4317360159 cites W2146274229 @default.
• W4317360159 cites W2148105436 @default.
• W4317360159 cites W2148294135 @default.
• W4317360159 cites W2155062762 @default.
• W4317360159 cites W2155070406 @default.
• W4317360159 cites W2159957100 @default.
• W4317360159 cites W2161444534 @default.
• W4317360159 cites W2166412761 @default.
• W4317360159 cites W2169613772 @default.
• W4317360159 cites W2403923438 @default.
• W4317360159 cites W2410650873 @default.
• W4317360159 cites W2523410070 @default.
• W4317360159 cites W2571477705 @default.
• W4317360159 cites W2580767461 @default.
• W4317360159 cites W2743353700 @default.
• W4317360159 cites W2911561283 @default.
• W4317360159 cites W2952005553 @default.
• W4317360159 cites W2969866109 @default.
• W4317360159 cites W2970147901 @default.
• W4317360159 cites W3016709954 @default.
• W4317360159 cites W3119774682 @default.
• W4317360159 cites W3125909203 @default.
• W4317360159 cites W3159719254 @default.
• W4317360159 cites W3162638989 @default.
• W4317360159 cites W3176890960 @default.
• W4317360159 cites W3184440907 @default.
• W4317360159 cites W4206689139 @default.
• W4317360159 cites W4213036305 @default.
• W4317360159 cites W4214718032 @default.
• W4317360159 cites W4220999759 @default.
• W4317360159 doi "https://doi.org/10.1007/s00239-022-10091-z" @default.
• W4317360159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36651963" @default.
• W4317360159 hasPublicationYear "2023" @default.
• W4317360159 type Work @default.
• W4317360159 citedByCount "0" @default.
• W4317360159 crossrefType "journal-article" @default.
• W4317360159 hasAuthorship W4317360159A5025731761 @default.
• W4317360159 hasAuthorship W4317360159A5037761662 @default.
• W4317360159 hasAuthorship W4317360159A5044849194 @default.
• W4317360159 hasAuthorship W4317360159A5089362139 @default.
• W4317360159 hasBestOaLocation W43173601591 @default.
• W4317360159 hasConcept C104317684 @default.
• W4317360159 hasConcept C141036 @default.
• W4317360159 hasConcept C141231307 @default.
• W4317360159 hasConcept C147897179 @default.
• W4317360159 hasConcept C166393388 @default.
• W4317360159 hasConcept C24586158 @default.

• next