Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317360780> ?p ?o ?g. }
- W4317360780 abstract "Helminth transmission and morbidity are dependent on the number of mature parasites within a host; however, observing adult worms is impossible for many natural infections. An outstanding challenge is therefore relating routine diagnostics, such as faecal egg counts, to the underlying worm burden. This relationship is complicated by density-dependent fecundity (egg output per worm reduces due to crowding at high burdens) and the skewed distribution of parasites (majority of helminths aggregated in a small fraction of hosts). We address these questions for the carcinogenic liver fluke Opisthorchis viverrini, which infects approximately 10 million people across Southeast Asia, by analysing five epidemiological surveys (n = 641) where adult flukes were recovered. Using a mechanistic model, we show that parasite fecundity varies between populations, with surveys from Thailand and Laos demonstrating distinct patterns of egg output and density-dependence. As the probability of observing faecal eggs increases with the number of mature parasites within a host, we quantify diagnostic sensitivity as a function of the worm burden and find that greater than 50% of cases are misdiagnosed as false negative in communities close to elimination. Finally, we demonstrate that the relationship between observed prevalence from routine diagnostics and true prevalence is nonlinear and strongly influenced by parasite aggregation." @default.
- W4317360780 created "2023-01-19" @default.
- W4317360780 creator A5005689730 @default.
- W4317360780 creator A5015201498 @default.
- W4317360780 creator A5028004630 @default.
- W4317360780 creator A5051300642 @default.
- W4317360780 creator A5058750137 @default.
- W4317360780 creator A5073827024 @default.
- W4317360780 creator A5081748718 @default.
- W4317360780 creator A5084313032 @default.
- W4317360780 date "2023-01-18" @default.
- W4317360780 modified "2023-10-14" @default.
- W4317360780 title "Diagnosis of helminths depends on worm fecundity and the distribution of parasites within hosts" @default.
- W4317360780 cites W1512318865 @default.
- W4317360780 cites W1565963867 @default.
- W4317360780 cites W159642811 @default.
- W4317360780 cites W162978041 @default.
- W4317360780 cites W1644145788 @default.
- W4317360780 cites W1967173283 @default.
- W4317360780 cites W1969622517 @default.
- W4317360780 cites W1977023430 @default.
- W4317360780 cites W1977753772 @default.
- W4317360780 cites W1991445071 @default.
- W4317360780 cites W1992099589 @default.
- W4317360780 cites W1992198528 @default.
- W4317360780 cites W199489817 @default.
- W4317360780 cites W1995459205 @default.
- W4317360780 cites W2020856801 @default.
- W4317360780 cites W2024921507 @default.
- W4317360780 cites W2052126028 @default.
- W4317360780 cites W2055195559 @default.
- W4317360780 cites W2056623977 @default.
- W4317360780 cites W2059655508 @default.
- W4317360780 cites W2065995561 @default.
- W4317360780 cites W2086709598 @default.
- W4317360780 cites W2087000698 @default.
- W4317360780 cites W2087095534 @default.
- W4317360780 cites W2101717153 @default.
- W4317360780 cites W2109616016 @default.
- W4317360780 cites W2114097264 @default.
- W4317360780 cites W2117616598 @default.
- W4317360780 cites W2123939899 @default.
- W4317360780 cites W2124009970 @default.
- W4317360780 cites W2124655534 @default.
- W4317360780 cites W2125920842 @default.
- W4317360780 cites W2126313821 @default.
- W4317360780 cites W2140535139 @default.
- W4317360780 cites W2141211553 @default.
- W4317360780 cites W2148778658 @default.
- W4317360780 cites W2149560245 @default.
- W4317360780 cites W2149591764 @default.
- W4317360780 cites W2164550478 @default.
- W4317360780 cites W2171619291 @default.
- W4317360780 cites W2190276977 @default.
- W4317360780 cites W2253183016 @default.
- W4317360780 cites W2261337234 @default.
- W4317360780 cites W2330951637 @default.
- W4317360780 cites W2334221770 @default.
- W4317360780 cites W2337933447 @default.
- W4317360780 cites W2409379059 @default.
- W4317360780 cites W2531295654 @default.
- W4317360780 cites W2577537660 @default.
- W4317360780 cites W2587608881 @default.
- W4317360780 cites W2619202610 @default.
- W4317360780 cites W2763039077 @default.
- W4317360780 cites W2769981215 @default.
- W4317360780 cites W2805320993 @default.
- W4317360780 cites W2807016289 @default.
- W4317360780 cites W2902664755 @default.
- W4317360780 cites W2910099164 @default.
- W4317360780 cites W2912303371 @default.
- W4317360780 cites W2912836442 @default.
- W4317360780 cites W2951580378 @default.
- W4317360780 cites W2972909080 @default.
- W4317360780 cites W3037769182 @default.
- W4317360780 cites W3121685411 @default.
- W4317360780 cites W3124727079 @default.
- W4317360780 cites W3159849667 @default.
- W4317360780 cites W3164193576 @default.
- W4317360780 cites W3187881808 @default.
- W4317360780 cites W3189168014 @default.
- W4317360780 cites W3202200645 @default.
- W4317360780 cites W4211059858 @default.
- W4317360780 cites W4220687318 @default.
- W4317360780 cites W4232976691 @default.
- W4317360780 cites W4285794103 @default.
- W4317360780 cites W4292948660 @default.
- W4317360780 cites W4317360780 @default.
- W4317360780 doi "https://doi.org/10.1098/rspb.2022.2204" @default.
- W4317360780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36651047" @default.
- W4317360780 hasPublicationYear "2023" @default.
- W4317360780 type Work @default.
- W4317360780 citedByCount "6" @default.
- W4317360780 countsByYear W43173607802023 @default.
- W4317360780 crossrefType "journal-article" @default.
- W4317360780 hasAuthorship W4317360780A5005689730 @default.
- W4317360780 hasAuthorship W4317360780A5015201498 @default.
- W4317360780 hasAuthorship W4317360780A5028004630 @default.
- W4317360780 hasAuthorship W4317360780A5051300642 @default.
- W4317360780 hasAuthorship W4317360780A5058750137 @default.