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- W4317366304 abstract "Review question / Objective: Oliceridine is a relatively novel so called bias opioid which is approved for severe opioid requiring pain. Due to its biased agonism, it is said to have fewer side effects than conventional opioids. This systematic review and meta-analysis will analyze the efficacy and effectiveness of oliceridine compared to placebo or morphine in acute postoperative pain for up to 72 hours. This will be the first meta-analysis on this topic. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. The lead questions of this systematic review and meta-analysis are: 1. Does Oliceridine demonstrate comparable analgesia to morphine with an improved side effect profile? 2. Does oliceridine demonstrate a superior analgesia compared to placebo with a comparable side effect profile? Transfered to PICOS, the study questions present as follows: Patients: Postoperative (up to 72hours) patients with moderate to severe pain Intervention: Oliceridine (TRV130) Comparison: Morphine and Placebo Outcome: Efficacy (pain reduction), effectiveness (side effects, adverse events) Study: Randomized controlled trials, at least single-blind." @default.
- W4317366304 created "2023-01-19" @default.
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- W4317366304 date "2023-01-19" @default.
- W4317366304 modified "2023-09-27" @default.
- W4317366304 title "Efficacy and effectiveness of Oliceridine in acute postoperative pain, a systematic review and meta-analysis" @default.
- W4317366304 doi "https://doi.org/10.37766/inplasy2023.1.0063" @default.
- W4317366304 hasPublicationYear "2023" @default.
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