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- W4317369563 abstract "Abstract Drug delivery into the peripheral nerves and nerve roots has important implications for effective local anesthesia and treatment of peripheral neuropathies and chronic neuropathic pain. Similar to drugs that need to cross the blood–brain barrier (BBB) and blood–spinal cord barrier to gain access to the central nervous system (CNS), drugs must cross the peripheral nerve barriers (PNBs), formed by the perineurium and blood–nerve barrier to modulate peripheral axons. Despite significant progress made to develop effective strategies to enhance BBB permeability in therapeutic drug design, efforts to enhance drug permeability and retention in peripheral nerves and nerve roots are relatively understudied. Guided by knowledge describing structural, molecular, and functional similarities between restrictive neural barriers in the CNS and peripheral nervous system, it is hypothesized that certain CNS drug delivery strategies are adaptable for peripheral nerve drug delivery. Here, the molecular, structural, and functional similarities and differences between the BBB and PNB are described, existing CNS and peripheral nerve drug delivery strategies are summarized and compared, and the potential application of selected CNS delivery strategies to improve efficacious drug entry for peripheral nerve disorders is discussed." @default.
- W4317369563 created "2023-01-19" @default.
- W4317369563 creator A5020746135 @default.
- W4317369563 creator A5034519027 @default.
- W4317369563 creator A5040375928 @default.
- W4317369563 creator A5050976823 @default.
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- W4317369563 creator A5084580172 @default.
- W4317369563 creator A5087448771 @default.
- W4317369563 creator A5089858947 @default.
- W4317369563 date "2023-02-09" @default.
- W4317369563 modified "2023-10-15" @default.
- W4317369563 title "Drug Permeability: From the Blood–Brain Barrier to the Peripheral Nerve Barriers" @default.
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