Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317373313> ?p ?o ?g. }
- W4317373313 abstract "Abstract Transition metal chemistry is essential to life, where metal binding to DNA, RNA, and proteins underpins all facets of the central dogma of biology. In this context, metals in proteins are typically studied as static active site cofactors. However, the emergence of transition metal signaling, where mobile metal pools can transiently bind to biological targets beyond active sites, is expanding this conventional view of bioinorganic chemistry. This Minireview focuses on the concept of metalloallostery, using copper as a canonical example of how metals can regulate protein function by binding to remote allosteric sites (e.g., exosites). We summarize advances in and prospects for the field, including imaging dynamic transition metal signaling pools, allosteric inhibition or activation of protein targets by metal binding, and metal‐dependent signaling pathways that underlie nutrient vulnerabilities in diseases spanning obesity, fatty liver disease, cancer, and neurodegeneration." @default.
- W4317373313 created "2023-01-19" @default.
- W4317373313 creator A5072113162 @default.
- W4317373313 creator A5090802384 @default.
- W4317373313 date "2023-01-18" @default.
- W4317373313 modified "2023-10-12" @default.
- W4317373313 title "Metalloallostery and Transition Metal Signaling: Bioinorganic Copper Chemistry Beyond Active Sites" @default.
- W4317373313 cites W1519459752 @default.
- W4317373313 cites W1968210490 @default.
- W4317373313 cites W1968611716 @default.
- W4317373313 cites W1968877792 @default.
- W4317373313 cites W1971326367 @default.
- W4317373313 cites W1974917614 @default.
- W4317373313 cites W1978059664 @default.
- W4317373313 cites W1981020468 @default.
- W4317373313 cites W1984132097 @default.
- W4317373313 cites W1995151567 @default.
- W4317373313 cites W1995713813 @default.
- W4317373313 cites W1997183854 @default.
- W4317373313 cites W2001731920 @default.
- W4317373313 cites W2011817526 @default.
- W4317373313 cites W2013976474 @default.
- W4317373313 cites W2014912105 @default.
- W4317373313 cites W2031441432 @default.
- W4317373313 cites W2034758552 @default.
- W4317373313 cites W2042624724 @default.
- W4317373313 cites W2045442119 @default.
- W4317373313 cites W2050672068 @default.
- W4317373313 cites W2051010986 @default.
- W4317373313 cites W2051986914 @default.
- W4317373313 cites W2055855305 @default.
- W4317373313 cites W2058449890 @default.
- W4317373313 cites W2061159332 @default.
- W4317373313 cites W2067265529 @default.
- W4317373313 cites W2067746388 @default.
- W4317373313 cites W2072383565 @default.
- W4317373313 cites W2074842308 @default.
- W4317373313 cites W2075873583 @default.
- W4317373313 cites W2076792457 @default.
- W4317373313 cites W2084931895 @default.
- W4317373313 cites W2086161594 @default.
- W4317373313 cites W2087279848 @default.
- W4317373313 cites W2087498165 @default.
- W4317373313 cites W2097929628 @default.
- W4317373313 cites W2115660554 @default.
- W4317373313 cites W2118480909 @default.
- W4317373313 cites W2122749282 @default.
- W4317373313 cites W2127974176 @default.
- W4317373313 cites W2130002263 @default.
- W4317373313 cites W2133789046 @default.
- W4317373313 cites W2141260882 @default.
- W4317373313 cites W2148904280 @default.
- W4317373313 cites W2149499310 @default.
- W4317373313 cites W2159294156 @default.
- W4317373313 cites W2171112077 @default.
- W4317373313 cites W2204688218 @default.
- W4317373313 cites W2228007557 @default.
- W4317373313 cites W226389138 @default.
- W4317373313 cites W230577079 @default.
- W4317373313 cites W240853074 @default.
- W4317373313 cites W2419048965 @default.
- W4317373313 cites W2493246000 @default.
- W4317373313 cites W2509231876 @default.
- W4317373313 cites W2535223986 @default.
- W4317373313 cites W2557950738 @default.
- W4317373313 cites W2560925534 @default.
- W4317373313 cites W2562236306 @default.
- W4317373313 cites W2598654686 @default.
- W4317373313 cites W2607808664 @default.
- W4317373313 cites W2765459934 @default.
- W4317373313 cites W2769036386 @default.
- W4317373313 cites W2782436857 @default.
- W4317373313 cites W2805791169 @default.
- W4317373313 cites W2897289019 @default.
- W4317373313 cites W2948833920 @default.
- W4317373313 cites W2951737470 @default.
- W4317373313 cites W2970405392 @default.
- W4317373313 cites W2980048937 @default.
- W4317373313 cites W3011699272 @default.
- W4317373313 cites W3019673916 @default.
- W4317373313 cites W3045355728 @default.
- W4317373313 cites W3093710085 @default.
- W4317373313 cites W3125208294 @default.
- W4317373313 cites W3131947862 @default.
- W4317373313 cites W3177828909 @default.
- W4317373313 cites W3185041137 @default.
- W4317373313 cites W3211795435 @default.
- W4317373313 cites W3212006797 @default.
- W4317373313 cites W4205911884 @default.
- W4317373313 cites W4213134081 @default.
- W4317373313 cites W4221115671 @default.
- W4317373313 cites W4281839846 @default.
- W4317373313 cites W4306641898 @default.
- W4317373313 cites W970644089 @default.
- W4317373313 doi "https://doi.org/10.1002/ange.202213644" @default.
- W4317373313 hasPublicationYear "2023" @default.
- W4317373313 type Work @default.
- W4317373313 citedByCount "0" @default.
- W4317373313 crossrefType "journal-article" @default.
- W4317373313 hasAuthorship W4317373313A5072113162 @default.