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- W4317383015 abstract "Abstract To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells." @default.
- W4317383015 created "2023-01-19" @default.
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- W4317383015 date "2023-01-18" @default.
- W4317383015 modified "2023-10-18" @default.
- W4317383015 title "Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface" @default.
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- W4317383015 doi "https://doi.org/10.1134/s160767292270003x" @default.
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