Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317387670> ?p ?o ?g. }
- W4317387670 endingPage "445" @default.
- W4317387670 startingPage "429" @default.
- W4317387670 abstract "Abstract As the world's population ages, the prevalence of age‐related neurological disorders such as Alzheimer's disease (AD) is increasing. There is currently no treatment for Alzheimer's disease, and the few approved medications have a low success rate in lowering symptoms. As a result, several attempts are underway worldwide to identify new targets for the therapy of Alzheimer's disease. In preclinical studies of Alzheimer's disease, it was recently found that inhibition of angiotensin‐converting enzyme (ACE) and blocking of the angiotensin II receptors reduce symptoms of neurodegeneration, Aβ plaque development, and tau hyperphosphorylation. Angiotensin II type I (AT1) blockers, such as telmisartan, candesartan, valsartan, and others, have a wide safety margin and are commonly used to treat hypertension. Renal and cardiovascular failures are reduced due to their vascular protective actions. Inhibition of AT1 receptors in the brain has a neuroprotective impact in humans, reducing the risk of stroke, increasing cognition, and slowing the progression of Alzheimer's disease. The review focuses on the mechanisms via which AT1 blockers may act beneficially in Alzheimer's disease. Although their effect is evident in preclinical studies, clinical trials, on the other hand, are in short supply to validate the strategy. More dose–response experiments with possible AT1 blockers and brain‐targeted administration will be needed in the future." @default.
- W4317387670 created "2023-01-19" @default.
- W4317387670 creator A5027729927 @default.
- W4317387670 creator A5056489724 @default.
- W4317387670 creator A5074767661 @default.
- W4317387670 date "2023-01-26" @default.
- W4317387670 modified "2023-10-01" @default.
- W4317387670 title "Role of angiotensin receptor blockers in the context of Alzheimer's disease" @default.
- W4317387670 cites W1130611829 @default.
- W4317387670 cites W1650328097 @default.
- W4317387670 cites W1922733151 @default.
- W4317387670 cites W1966621863 @default.
- W4317387670 cites W1970694369 @default.
- W4317387670 cites W1972072236 @default.
- W4317387670 cites W1973831406 @default.
- W4317387670 cites W1977995694 @default.
- W4317387670 cites W1981132320 @default.
- W4317387670 cites W1995817686 @default.
- W4317387670 cites W2000362399 @default.
- W4317387670 cites W2000772328 @default.
- W4317387670 cites W2012746420 @default.
- W4317387670 cites W2017213641 @default.
- W4317387670 cites W2025072503 @default.
- W4317387670 cites W2037387044 @default.
- W4317387670 cites W2041859381 @default.
- W4317387670 cites W2047385780 @default.
- W4317387670 cites W2048811481 @default.
- W4317387670 cites W2052321977 @default.
- W4317387670 cites W2052766986 @default.
- W4317387670 cites W2060926663 @default.
- W4317387670 cites W2061411812 @default.
- W4317387670 cites W2062034516 @default.
- W4317387670 cites W2062971918 @default.
- W4317387670 cites W2064823654 @default.
- W4317387670 cites W2067956701 @default.
- W4317387670 cites W2067981526 @default.
- W4317387670 cites W2070448139 @default.
- W4317387670 cites W2073437770 @default.
- W4317387670 cites W2073545472 @default.
- W4317387670 cites W2075136899 @default.
- W4317387670 cites W2081508447 @default.
- W4317387670 cites W2085435800 @default.
- W4317387670 cites W2087318599 @default.
- W4317387670 cites W2090314376 @default.
- W4317387670 cites W2094808560 @default.
- W4317387670 cites W2106122924 @default.
- W4317387670 cites W2108492672 @default.
- W4317387670 cites W2110123670 @default.
- W4317387670 cites W2116485041 @default.
- W4317387670 cites W2120063106 @default.
- W4317387670 cites W2134475193 @default.
- W4317387670 cites W2138574163 @default.
- W4317387670 cites W2150851826 @default.
- W4317387670 cites W2157942810 @default.
- W4317387670 cites W2163460744 @default.
- W4317387670 cites W2163635092 @default.
- W4317387670 cites W2169800603 @default.
- W4317387670 cites W2198664180 @default.
- W4317387670 cites W2205961273 @default.
- W4317387670 cites W2279327176 @default.
- W4317387670 cites W2329336071 @default.
- W4317387670 cites W2346415150 @default.
- W4317387670 cites W2402393879 @default.
- W4317387670 cites W2566039288 @default.
- W4317387670 cites W2576150045 @default.
- W4317387670 cites W2606499526 @default.
- W4317387670 cites W2622491282 @default.
- W4317387670 cites W2738888781 @default.
- W4317387670 cites W2745540955 @default.
- W4317387670 cites W2765546586 @default.
- W4317387670 cites W2766388141 @default.
- W4317387670 cites W2790475912 @default.
- W4317387670 cites W2791138970 @default.
- W4317387670 cites W2800574431 @default.
- W4317387670 cites W2804592477 @default.
- W4317387670 cites W2805257646 @default.
- W4317387670 cites W2806295635 @default.
- W4317387670 cites W2806823430 @default.
- W4317387670 cites W2896002881 @default.
- W4317387670 cites W2896295338 @default.
- W4317387670 cites W2896669678 @default.
- W4317387670 cites W2913440408 @default.
- W4317387670 cites W2944647323 @default.
- W4317387670 cites W2945333307 @default.
- W4317387670 cites W2947266911 @default.
- W4317387670 cites W2980436535 @default.
- W4317387670 cites W2996903151 @default.
- W4317387670 cites W3004207308 @default.
- W4317387670 cites W3028087724 @default.
- W4317387670 cites W3200376971 @default.
- W4317387670 doi "https://doi.org/10.1111/fcp.12872" @default.
- W4317387670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36654189" @default.
- W4317387670 hasPublicationYear "2023" @default.
- W4317387670 type Work @default.
- W4317387670 citedByCount "1" @default.
- W4317387670 countsByYear W43173876702023 @default.
- W4317387670 crossrefType "journal-article" @default.
- W4317387670 hasAuthorship W4317387670A5027729927 @default.