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- W4317387795 abstract "UDP-glycosyltransferases (UGTs), important enzymes in biotransformation, control the levels and distribution of numerous endogenous signaling molecules and the metabolism of a wide range of endogenous and exogenous chemicals. The UGT superfamily in mammals consists of the UGT1, UGT2, UGT3, and UGT8 families. UGTs are rate-limiting enzymes in the glucuronate pathway, and in tumors, they are either overexpressed or underexpressed. Alterations in their metabolism can affect gluconeogenesis and lipid metabolism pathways, leading to alterations in tumor cell metabolism, which affect cancer development and prognosis. Glucuronidation is the most common mammalian conjugation pathway. Most of its reactions are mainly catalyzed by UGT1A, UGT2A and UGT2B. The body excretes UGT-bound small lipophilic molecules through the bile, urine, or feces. UGTs conjugate a variety of tiny lipophilic molecules to sugars, such as galactose, xylose, acetylglucosamine, glucuronic acid, and glucose, thereby inactivating and making water-soluble substrates, such as carcinogens, medicines, steroids, lipids, fatty acids, and bile acids. This review summarizes the roles of members of the four UGT enzyme families in tumor function, metabolism, and multiple regulatory mechanisms, and its Inhibitors and inducers. The function of UGTs in lipid metabolism, drug metabolism, and hormone metabolism in tumor cells are among the most important topics covered." @default.
- W4317387795 created "2023-01-19" @default.
- W4317387795 creator A5012677271 @default.
- W4317387795 creator A5032279676 @default.
- W4317387795 creator A5039146544 @default.
- W4317387795 creator A5041282060 @default.
- W4317387795 creator A5075068668 @default.
- W4317387795 date "2023-01-19" @default.
- W4317387795 modified "2023-09-29" @default.
- W4317387795 title "The Uridine diphosphate (UDP)-glycosyltransferases (UGTs) superfamily: the role in tumor cell metabolism" @default.
- W4317387795 cites W144423133 @default.
- W4317387795 cites W1546874842 @default.
- W4317387795 cites W1599124340 @default.
- W4317387795 cites W173798027 @default.
- W4317387795 cites W1762686207 @default.
- W4317387795 cites W1909553894 @default.
- W4317387795 cites W1974651587 @default.
- W4317387795 cites W1981918114 @default.
- W4317387795 cites W1994036293 @default.
- W4317387795 cites W1994296775 @default.
- W4317387795 cites W1996777291 @default.
- W4317387795 cites W2006226859 @default.
- W4317387795 cites W2010396428 @default.
- W4317387795 cites W2011607101 @default.
- W4317387795 cites W2020822445 @default.
- W4317387795 cites W2020994990 @default.
- W4317387795 cites W2021636584 @default.
- W4317387795 cites W2021928168 @default.
- W4317387795 cites W2022098505 @default.
- W4317387795 cites W2027713583 @default.
- W4317387795 cites W2029339636 @default.
- W4317387795 cites W2033250981 @default.
- W4317387795 cites W2036069930 @default.
- W4317387795 cites W2041804792 @default.
- W4317387795 cites W2042537262 @default.
- W4317387795 cites W2045042834 @default.
- W4317387795 cites W2049537372 @default.
- W4317387795 cites W2056955168 @default.
- W4317387795 cites W2059206417 @default.
- W4317387795 cites W2064147706 @default.
- W4317387795 cites W2064803785 @default.
- W4317387795 cites W2068523650 @default.
- W4317387795 cites W2069184780 @default.
- W4317387795 cites W2070000009 @default.
- W4317387795 cites W2072497364 @default.
- W4317387795 cites W2073428316 @default.
- W4317387795 cites W2073647466 @default.
- W4317387795 cites W2075089790 @default.
- W4317387795 cites W2079951144 @default.
- W4317387795 cites W2080131949 @default.
- W4317387795 cites W2084369338 @default.
- W4317387795 cites W2089923064 @default.
- W4317387795 cites W2090408147 @default.
- W4317387795 cites W2098243593 @default.
- W4317387795 cites W2099474750 @default.
- W4317387795 cites W2102892253 @default.
- W4317387795 cites W2104115696 @default.
- W4317387795 cites W2105396478 @default.
- W4317387795 cites W2106189539 @default.
- W4317387795 cites W2107794583 @default.
- W4317387795 cites W2115277036 @default.
- W4317387795 cites W2116201681 @default.
- W4317387795 cites W2117906220 @default.
- W4317387795 cites W2119995130 @default.
- W4317387795 cites W2123979498 @default.
- W4317387795 cites W2126351303 @default.
- W4317387795 cites W2132804094 @default.
- W4317387795 cites W2133212034 @default.
- W4317387795 cites W2137285308 @default.
- W4317387795 cites W2138509705 @default.
- W4317387795 cites W2144266807 @default.
- W4317387795 cites W2144731680 @default.
- W4317387795 cites W2148501124 @default.
- W4317387795 cites W2159660532 @default.
- W4317387795 cites W2168886345 @default.
- W4317387795 cites W2185458335 @default.
- W4317387795 cites W2258466302 @default.
- W4317387795 cites W2280472166 @default.
- W4317387795 cites W2293876892 @default.
- W4317387795 cites W2401738727 @default.
- W4317387795 cites W2438847376 @default.
- W4317387795 cites W2501244830 @default.
- W4317387795 cites W2514536404 @default.
- W4317387795 cites W2517592827 @default.
- W4317387795 cites W2520695216 @default.
- W4317387795 cites W2523469334 @default.
- W4317387795 cites W2526663955 @default.
- W4317387795 cites W2535363557 @default.
- W4317387795 cites W2564137162 @default.
- W4317387795 cites W2605206322 @default.
- W4317387795 cites W2618034562 @default.
- W4317387795 cites W2750259820 @default.
- W4317387795 cites W2761075576 @default.
- W4317387795 cites W2765486709 @default.
- W4317387795 cites W2790688445 @default.
- W4317387795 cites W2792031296 @default.
- W4317387795 cites W2800788478 @default.
- W4317387795 cites W2804423573 @default.
- W4317387795 cites W2805380335 @default.
- W4317387795 cites W2805417487 @default.