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• W4317423816 startingPage "284" @default.
• W4317423816 abstract "Virus-cell interactions involve fundamental parameters that need to be considered in strategies implemented to control viral outbreaks. Among these, the surface electrostatic potential can give valuable information to deal with new epidemics. In this article, we describe the role of this key parameter in the hemagglutination of red blood cells and in the co-evolution of synaptic receptors and neurotransmitters. We then establish the functional link between lipid rafts and the electrostatic potential of viruses, with special emphasis on gangliosides, which are sialic-acid-containing, electronegatively charged plasma membrane components. We describe the common features of ganglioside binding domains, which include a wide variety of structures with little sequence homology but that possess key amino acids controlling ganglioside recognition. We analyze the role of the electrostatic potential in the transmission and intra-individual evolution of HIV-1 infections, including gatekeeper and co-receptor switch mechanisms. We show how to organize the epidemic surveillance of influenza viruses by focusing on mutations affecting the hemagglutinin surface potential. We demonstrate that the electrostatic surface potential, by modulating spike-ganglioside interactions, controls the hemagglutination properties of coronaviruses (SARS-CoV-1, MERS-CoV, and SARS-CoV-2) as well as the structural dynamics of SARS-CoV-2 evolution. We relate the broad-spectrum antiviral activity of repositioned molecules to their ability to disrupt virus-raft interactions, challenging the old concept that an antibiotic or anti-parasitic cannot also be an antiviral. We propose a new concept based on the analysis of the electrostatic surface potential to develop, in real time, therapeutic and vaccine strategies adapted to each new viral epidemic." @default.
• W4317423816 created "2023-01-19" @default.
• W4317423816 creator A5027587090 @default.
• W4317423816 creator A5046563473 @default.
• W4317423816 creator A5047254221 @default.
• W4317423816 creator A5062841099 @default.
• W4317423816 date "2023-01-19" @default.
• W4317423816 modified "2023-10-16" @default.
• W4317423816 title "Electrostatic Surface Potential as a Key Parameter in Virus Transmission and Evolution: How to Manage Future Virus Pandemics in the Post-COVID-19 Era" @default.
• W4317423816 cites W1488862635 @default.
• W4317423816 cites W1524992328 @default.
• W4317423816 cites W1552785739 @default.
• W4317423816 cites W1622684250 @default.
• W4317423816 cites W1964441398 @default.
• W4317423816 cites W1966261980 @default.
• W4317423816 cites W1967778765 @default.
• W4317423816 cites W1967802147 @default.
• W4317423816 cites W1969017401 @default.
• W4317423816 cites W1972173415 @default.
• W4317423816 cites W1979158913 @default.
• W4317423816 cites W1983748012 @default.
• W4317423816 cites W1984215395 @default.
• W4317423816 cites W1990437495 @default.
• W4317423816 cites W1993357003 @default.
• W4317423816 cites W1998674683 @default.
• W4317423816 cites W1999012053 @default.
• W4317423816 cites W1999192293 @default.
• W4317423816 cites W2002659345 @default.
• W4317423816 cites W2003040183 @default.
• W4317423816 cites W2007055954 @default.
• W4317423816 cites W2009296046 @default.
• W4317423816 cites W2010003862 @default.
• W4317423816 cites W2014346706 @default.
• W4317423816 cites W2017410358 @default.
• W4317423816 cites W2021534482 @default.
• W4317423816 cites W2024684978 @default.
• W4317423816 cites W2027993877 @default.
• W4317423816 cites W2030534984 @default.
• W4317423816 cites W2031305384 @default.
• W4317423816 cites W2035347499 @default.
• W4317423816 cites W2036036213 @default.
• W4317423816 cites W2036428031 @default.
• W4317423816 cites W2040725659 @default.
• W4317423816 cites W2040846532 @default.
• W4317423816 cites W2042587442 @default.
• W4317423816 cites W2043559051 @default.
• W4317423816 cites W2044777804 @default.
• W4317423816 cites W2044874413 @default.
• W4317423816 cites W2051062943 @default.
• W4317423816 cites W2055295979 @default.
• W4317423816 cites W2058403143 @default.
• W4317423816 cites W2060304556 @default.
• W4317423816 cites W2067606575 @default.
• W4317423816 cites W2068261603 @default.
• W4317423816 cites W2069094887 @default.
• W4317423816 cites W2071398804 @default.
• W4317423816 cites W2074916511 @default.
• W4317423816 cites W2077494883 @default.
• W4317423816 cites W2079113070 @default.
• W4317423816 cites W2079655614 @default.
• W4317423816 cites W2079853441 @default.
• W4317423816 cites W2081270303 @default.
• W4317423816 cites W2087793829 @default.
• W4317423816 cites W2088222944 @default.
• W4317423816 cites W2088816361 @default.
• W4317423816 cites W2096813500 @default.
• W4317423816 cites W2097336110 @default.
• W4317423816 cites W2102265386 @default.
• W4317423816 cites W2109928552 @default.
• W4317423816 cites W2110641467 @default.
• W4317423816 cites W2112044573 @default.
• W4317423816 cites W2115145238 @default.
• W4317423816 cites W2117816244 @default.
• W4317423816 cites W2119111857 @default.
• W4317423816 cites W2122574965 @default.
• W4317423816 cites W2122977671 @default.
• W4317423816 cites W2123827168 @default.
• W4317423816 cites W2124170577 @default.
• W4317423816 cites W2124846613 @default.
• W4317423816 cites W2143360782 @default.
• W4317423816 cites W2143597049 @default.
• W4317423816 cites W2148711543 @default.
• W4317423816 cites W2148781850 @default.
• W4317423816 cites W2148970839 @default.
• W4317423816 cites W2153052569 @default.
• W4317423816 cites W2156182155 @default.
• W4317423816 cites W2158754803 @default.
• W4317423816 cites W2162885289 @default.
• W4317423816 cites W2165327829 @default.
• W4317423816 cites W2166867592 @default.
• W4317423816 cites W2167554327 @default.
• W4317423816 cites W2344808617 @default.
• W4317423816 cites W2408590796 @default.
• W4317423816 cites W2413214643 @default.
• W4317423816 cites W2415353984 @default.
• W4317423816 cites W2460792530 @default.
• W4317423816 cites W2506093338 @default.
• W4317423816 cites W2516533647 @default.

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