Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317434387> ?p ?o ?g. }
- W4317434387 endingPage "509" @default.
- W4317434387 startingPage "509" @default.
- W4317434387 abstract "The novel thermosensitive star-shaped tetra-hydroxy-phenylporphyrin-cored (THPP) double hydrophilic poly(N-isopropylacrylamide)-b-poly(methylacrylamide glucose) block copolymers (THPP-(PNIPAM-b-PMAGA)4) were synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization. Notably, the low critical solution temperatures (LCSTs) of THPP-(PNIPAM-b-PMAGA)4 were above normal body temperature (37 °C) which depended on the hydrophilic PMAGA contents of copolymers. When the temperature was higher than the LCST of the copolymer, the copolymer could be neutralized into micelles in aqueous and could be coated with antitumor drugs and released around tumor cells. The MTT study indicated that THPP-(PNIPAM-b-PMAGA)4 had a low toxicity to L929 and HeLa cells in the absence of light. However, THPP-(PNIPAM-b-PMAGA)4 showed a high toxicity with HeLa cells under light irradiation which could be used as a potential photosensitizer for photodynamic therapy (PDT). In addition, THPP-(PNIPAM-b-PMAGA)4 showed specific a recognition function with Concanavalin A (Con A) to achieve active targeted drug delivery. This work provides a new approach for the development of tumor targeting and chemotherapy/PDT." @default.
- W4317434387 created "2023-01-19" @default.
- W4317434387 creator A5024952249 @default.
- W4317434387 creator A5025904134 @default.
- W4317434387 creator A5037475520 @default.
- W4317434387 creator A5039932767 @default.
- W4317434387 creator A5064621294 @default.
- W4317434387 creator A5065026444 @default.
- W4317434387 creator A5082637396 @default.
- W4317434387 date "2023-01-18" @default.
- W4317434387 modified "2023-09-24" @default.
- W4317434387 title "A Star-Shaped Copolymer with Tetra-Hydroxy-Phenylporphyrin Core and Four PNIPAM-b-PMAGA Arms for Targeted Photodynamic Therapy" @default.
- W4317434387 cites W1481617938 @default.
- W4317434387 cites W1576437441 @default.
- W4317434387 cites W1965650017 @default.
- W4317434387 cites W1967945887 @default.
- W4317434387 cites W1971817705 @default.
- W4317434387 cites W1973319489 @default.
- W4317434387 cites W1974772173 @default.
- W4317434387 cites W1975088956 @default.
- W4317434387 cites W1978964983 @default.
- W4317434387 cites W1980109834 @default.
- W4317434387 cites W1994486848 @default.
- W4317434387 cites W1994564484 @default.
- W4317434387 cites W1995325846 @default.
- W4317434387 cites W1998439254 @default.
- W4317434387 cites W2016747572 @default.
- W4317434387 cites W2020515864 @default.
- W4317434387 cites W2022743550 @default.
- W4317434387 cites W2026100316 @default.
- W4317434387 cites W2029890180 @default.
- W4317434387 cites W2030882853 @default.
- W4317434387 cites W2039199651 @default.
- W4317434387 cites W2040338711 @default.
- W4317434387 cites W2048582601 @default.
- W4317434387 cites W2050186721 @default.
- W4317434387 cites W2055684927 @default.
- W4317434387 cites W2058319021 @default.
- W4317434387 cites W2068996255 @default.
- W4317434387 cites W2072298860 @default.
- W4317434387 cites W2083496490 @default.
- W4317434387 cites W2086155660 @default.
- W4317434387 cites W2091756300 @default.
- W4317434387 cites W2092700187 @default.
- W4317434387 cites W2093860844 @default.
- W4317434387 cites W2105014780 @default.
- W4317434387 cites W2105913803 @default.
- W4317434387 cites W2129423581 @default.
- W4317434387 cites W2146646926 @default.
- W4317434387 cites W2149984051 @default.
- W4317434387 cites W2152764444 @default.
- W4317434387 cites W2164603651 @default.
- W4317434387 cites W2165888895 @default.
- W4317434387 cites W2325414222 @default.
- W4317434387 cites W2345902039 @default.
- W4317434387 cites W2593218519 @default.
- W4317434387 cites W2605514081 @default.
- W4317434387 cites W2733078685 @default.
- W4317434387 cites W2886940947 @default.
- W4317434387 cites W2995600321 @default.
- W4317434387 cites W3004100740 @default.
- W4317434387 cites W3164150151 @default.
- W4317434387 cites W4241409678 @default.
- W4317434387 cites W4254534600 @default.
- W4317434387 doi "https://doi.org/10.3390/polym15030509" @default.
- W4317434387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36771810" @default.
- W4317434387 hasPublicationYear "2023" @default.
- W4317434387 type Work @default.
- W4317434387 citedByCount "0" @default.
- W4317434387 crossrefType "journal-article" @default.
- W4317434387 hasAuthorship W4317434387A5024952249 @default.
- W4317434387 hasAuthorship W4317434387A5025904134 @default.
- W4317434387 hasAuthorship W4317434387A5037475520 @default.
- W4317434387 hasAuthorship W4317434387A5039932767 @default.
- W4317434387 hasAuthorship W4317434387A5064621294 @default.
- W4317434387 hasAuthorship W4317434387A5065026444 @default.
- W4317434387 hasAuthorship W4317434387A5082637396 @default.
- W4317434387 hasBestOaLocation W43174343871 @default.
- W4317434387 hasConcept C111998727 @default.
- W4317434387 hasConcept C11268172 @default.
- W4317434387 hasConcept C121120078 @default.
- W4317434387 hasConcept C13965031 @default.
- W4317434387 hasConcept C15920480 @default.
- W4317434387 hasConcept C159985019 @default.
- W4317434387 hasConcept C178790620 @default.
- W4317434387 hasConcept C184651966 @default.
- W4317434387 hasConcept C185592680 @default.
- W4317434387 hasConcept C188027245 @default.
- W4317434387 hasConcept C188109995 @default.
- W4317434387 hasConcept C192562407 @default.
- W4317434387 hasConcept C202751555 @default.
- W4317434387 hasConcept C2777366897 @default.
- W4317434387 hasConcept C2781323092 @default.
- W4317434387 hasConcept C2781469039 @default.
- W4317434387 hasConcept C34594497 @default.
- W4317434387 hasConcept C44228677 @default.
- W4317434387 hasConcept C521977710 @default.
- W4317434387 hasConcept C55493867 @default.