FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317435306> ?p ?o ?g. }

• W4317435306 endingPage "111" @default.
• W4317435306 startingPage "99" @default.
• W4317435306 abstract "Background: It is recognized increasingly that common surgical infections of the peritoneal cavity may be treated with antibiotic agents alone, or source control surgery with short-course antimicrobial therapy. By extension, testable hypotheses have emerged that such infections may not actually be infectious diseases, but rather represent inflammation that can be treated successfully with neither surgery nor antibiotic agents. The aim of this review is to examine extant data to determine which of uncomplicated acute appendicitis (uAA), uncomplicated acute calculous cholecystitis (uACC), or uncomplicated mild acute diverticulitis (umAD) might be amenable to management using supportive therapy alone, consistent with the principles of antimicrobial stewardship. Methods: Review of pertinent English-language literature and expert opinion. Results: Only two small trials have examined whether uAA can be managed with observation and supportive therapy alone, one of which is underpowered and was stopped prematurely because of challenging patient recruitment. Data are insufficient to determine the safety and efficacy of non-antibiotic therapy of uAA. Uncomplicated acute calculous cholecystitis is not primarily an infectious disease; infection is a secondary phenomenon. Even when bactibilia is present, there is no high-quality evidence to suggest that mild disease should be treated with antibiotic agents. There is evidence to indicate that antibiotic prophylaxis is indicated for urgent/emergency cholecystectomy for uACC, but not in the post-operative period. Uncomplicated mild acute diverticulitis, generally Hinchey 1a or 1b in current nomenclature, does not benefit from antimicrobial agents based on multiple clinical studies. The implication is that umAD is inflammatory and not an infectious disease. Non-antimicrobial management is reasonable. Conclusions: Among the considered disease entities, the evidence is strongest that umAD is not an infectious disease and can be treated without antibiotic agents, intermediate regarding uACC, and lacking for uAA. A plausible hypothesis is that these inflammatory conditions are related to disruption of the normal microbiome, resulting in dysbiosis, which is defined as an imbalance of the natural microflora, especially of the gut, that is believed to contribute to a range of conditions of ill health. As for restorative pre- or probiotic therapy to reconstitute the microbiome, no recommendation can be made in terms of treatment, but it is not recommended for prevention of primary or recurrent disease." @default.
• W4317435306 created "2023-01-19" @default.
• W4317435306 creator A5016100688 @default.
• W4317435306 creator A5022085835 @default.
• W4317435306 creator A5031168832 @default.
• W4317435306 creator A5078153822 @default.
• W4317435306 date "2023-03-01" @default.
• W4317435306 modified "2023-10-17" @default.
• W4317435306 title "Infection or Inflammation: Are Uncomplicated Acute Appendicitis, Acute Cholecystitis, and Acute Diverticulitis Infectious Diseases?" @default.
• W4317435306 cites W1964266579 @default.
• W4317435306 cites W1965496988 @default.
• W4317435306 cites W1968401642 @default.
• W4317435306 cites W1972739323 @default.
• W4317435306 cites W1973052704 @default.
• W4317435306 cites W1979509987 @default.
• W4317435306 cites W1982449562 @default.
• W4317435306 cites W1986680943 @default.
• W4317435306 cites W1995409470 @default.
• W4317435306 cites W1996232615 @default.
• W4317435306 cites W1997222976 @default.
• W4317435306 cites W2005360630 @default.
• W4317435306 cites W2005636584 @default.
• W4317435306 cites W2017626638 @default.
• W4317435306 cites W2018134535 @default.
• W4317435306 cites W2019352787 @default.
• W4317435306 cites W2023402348 @default.
• W4317435306 cites W2038390761 @default.
• W4317435306 cites W2039602526 @default.
• W4317435306 cites W2041506665 @default.
• W4317435306 cites W2045708345 @default.
• W4317435306 cites W2056411053 @default.
• W4317435306 cites W2056480872 @default.
• W4317435306 cites W2056649728 @default.
• W4317435306 cites W2059452100 @default.
• W4317435306 cites W2068355253 @default.
• W4317435306 cites W2075494029 @default.
• W4317435306 cites W2081995871 @default.
• W4317435306 cites W2082693656 @default.
• W4317435306 cites W2090793634 @default.
• W4317435306 cites W2094946309 @default.
• W4317435306 cites W2097728658 @default.
• W4317435306 cites W2099568368 @default.
• W4317435306 cites W2102187963 @default.
• W4317435306 cites W2123151246 @default.
• W4317435306 cites W2125640272 @default.
• W4317435306 cites W2138695773 @default.
• W4317435306 cites W2148077193 @default.
• W4317435306 cites W2172342875 @default.
• W4317435306 cites W2197932204 @default.
• W4317435306 cites W2265914419 @default.
• W4317435306 cites W2289275765 @default.
• W4317435306 cites W2315194987 @default.
• W4317435306 cites W2411124584 @default.
• W4317435306 cites W2418296568 @default.
• W4317435306 cites W2493849007 @default.
• W4317435306 cites W2500873626 @default.
• W4317435306 cites W2520183518 @default.
• W4317435306 cites W2525803483 @default.
• W4317435306 cites W2535900974 @default.
• W4317435306 cites W2555549036 @default.
• W4317435306 cites W2561287114 @default.
• W4317435306 cites W2589009562 @default.
• W4317435306 cites W2594855679 @default.
• W4317435306 cites W2606389788 @default.
• W4317435306 cites W2623085584 @default.
• W4317435306 cites W2625051027 @default.
• W4317435306 cites W2756475099 @default.
• W4317435306 cites W2762299493 @default.
• W4317435306 cites W2763151664 @default.
• W4317435306 cites W2765814213 @default.
• W4317435306 cites W2770180966 @default.
• W4317435306 cites W2777559426 @default.
• W4317435306 cites W2799316157 @default.
• W4317435306 cites W2810104981 @default.
• W4317435306 cites W2888723784 @default.
• W4317435306 cites W2890403222 @default.
• W4317435306 cites W2895397067 @default.
• W4317435306 cites W2898759240 @default.
• W4317435306 cites W2902324317 @default.
• W4317435306 cites W2906150927 @default.
• W4317435306 cites W2908839642 @default.
• W4317435306 cites W2910435778 @default.
• W4317435306 cites W2913994552 @default.
• W4317435306 cites W2921699066 @default.
• W4317435306 cites W2922031332 @default.
• W4317435306 cites W2962884778 @default.
• W4317435306 cites W2964932371 @default.
• W4317435306 cites W2968063898 @default.
• W4317435306 cites W2969808663 @default.
• W4317435306 cites W2972216412 @default.
• W4317435306 cites W2977343267 @default.
• W4317435306 cites W2989645972 @default.
• W4317435306 cites W2992764683 @default.
• W4317435306 cites W2997823537 @default.
• W4317435306 cites W2998513439 @default.
• W4317435306 cites W3009007316 @default.
• W4317435306 cites W3014658997 @default.
• W4317435306 cites W3022871146 @default.

• next