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- W4317436301 abstract "Abstract Background: The familial chylomicronemia syndrome (FCS) is an ultra rare disease caused by lipoprotein lipase (LPL) deficiency associated with potentially lethal acute pancreatitis risk. Thrombocytopenia (platelet count < 150,000 x 10 9 /L) has been reported in patients with FCS, treated or not with volanesorsen, a second generation APOC3 anti-sense oligonucleotide. Chylomicrons are the lipoproteins delivering fat after a meal and FCS is thus a post-prandial disease. Platelet count and activity have not been studied post-prandially in FCS. Objective: To evaluate post-prandial fluctuations in the platelet count (PLC) and platelet activity in FCS. Methods: PLC, platelet activity and hematologic variables were measured up-to 5 hours after a meal in 6 homozygotes for FCS causing gene variants (HoLPL), 6 heterozygotes for LPL loss-of-function variants (HeLPL) and 7 normolipidemic controls. Results : Hourly post-prandial PLC was significantly lower in HoLPL than in controls (p< 0.009). Compared to the other groups, the PLC tended to decrease rapidly (in the first hour) post-meal in HoLPL (p=0.03) and remained lower than baseline 5-hour post-meal (p=0.02) whereas it tended to slightly increase in normolipidemic controls (p=0.02). Platelet activity was not affected by the prandial status. In HoLPL, post-prandial fluctuations in the PLC positively correlated with the lymphocyte count (p=0.005) and negatively with neutrophil/lymphocyte ratio (NLR). Conclusion : The PLC decreases post-prandially in FCS (HoLPL), is not associated with changes in platelet activity and correlates with the NLR, a marker of acute pancreatitis severity." @default.
- W4317436301 created "2023-01-19" @default.
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- W4317436301 date "2023-01-19" @default.
- W4317436301 modified "2023-10-04" @default.
- W4317436301 title "Post-prandial Analysis of Fluctuations in the Platelet Count and Platelet Activity in Patients with the Familial Chylomicronemia Syndrome" @default.
- W4317436301 doi "https://doi.org/10.21203/rs.3.rs-2443467/v1" @default.
- W4317436301 hasPublicationYear "2023" @default.
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