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- W4317436510 abstract "The presence of insoluble protein deposits in tissues and organs is a hallmark of many human pathologies. In addition, the formation of protein aggregates is considered one of the main bottlenecks to producing protein-based therapeutics. Thus, there is a high interest in rationalizing and predicting protein aggregation. For almost two decades, our laboratory has been working to provide solutions for these needs. We have traditionally combined the core tenets of both bioinformatics and wet lab biophysics to develop algorithms and databases to study protein aggregation and its functional implications. Here, we review the computational toolbox developed by our lab, including programs for identifying sequential or structural aggregation-prone regions at the individual protein and proteome levels, engineering protein solubility, finding and evaluating prion-like domains, studying disorder-to-order protein transitions, or categorizing non-conventional amyloid regions of polar nature, among others. In perspective, the succession of the tools we describe illustrates how our understanding of the protein aggregation phenomenon has evolved over the last fifteen years." @default.
- W4317436510 created "2023-01-19" @default.
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- W4317436510 creator A5010277918 @default.
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- W4317436510 creator A5053487672 @default.
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- W4317436510 creator A5082882823 @default.
- W4317436510 date "2023-01-18" @default.
- W4317436510 modified "2023-10-12" @default.
- W4317436510 title "A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation" @default.
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