FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317436732> ?p ?o ?g. }

• W4317436732 endingPage "157" @default.
• W4317436732 startingPage "157" @default.
• W4317436732 abstract "Boosting trophic support to striatal neurons by increasing levels of brain-derived neurotrophic factor (BDNF) has been considered as a target for therapeutic intervention for several neurodegenerative diseases, including Huntington's disease (HD). To aid in the implementation of such a strategy, a thorough understanding of BDNF cortical-striatal transport is critical to help guide its strategic delivery. In this manuscript, we investigate the dynamic behavior of BDNF transport along the cortical-striatal axis in Q140 primary neurons, a mouse model for HD. We examine this by using single-molecule labeling of BDNF conjugated with quantum dots (QD-BDNF) to follow the transport along the cortical-striatal axis in a microfluidic chamber system specifically designed for the co-culture of cortical and striatal primary neurons. Using this approach, we observe a defect of QD-BDNF transport in Q140 neurons. Our study demonstrates that QD-BDNF transport along the cortical-striatal axis involves the impairment of anterograde transport within axons of cortical neurons, and of retrograde transport within dendrites of striatal neurons. One prominent feature we observe is the extended pause time of QD-BDNF retrograde transport within Q140 striatal dendrites. Taken together, these finding support the hypothesis that delinquent spatiotemporal trophic support of BDNF to striatal neurons, driven by impaired transport, may contribute to the pathogenesis of HD, providing us with insight into how a BDNF supplementation therapeutic strategy may best be applied for HD." @default.
• W4317436732 created "2023-01-19" @default.
• W4317436732 creator A5020390335 @default.
• W4317436732 creator A5023173990 @default.
• W4317436732 creator A5033337188 @default.
• W4317436732 creator A5033555654 @default.
• W4317436732 creator A5043741112 @default.
• W4317436732 creator A5046597133 @default.
• W4317436732 creator A5051631944 @default.
• W4317436732 creator A5065081963 @default.
• W4317436732 creator A5069475070 @default.
• W4317436732 creator A5070285689 @default.
• W4317436732 creator A5078385790 @default.
• W4317436732 creator A5082419721 @default.
• W4317436732 creator A5082854869 @default.
• W4317436732 date "2023-01-19" @default.
• W4317436732 modified "2023-10-17" @default.
• W4317436732 title "Failure to Thrive: Impaired BDNF Transport along the Cortical–Striatal Axis in Mouse Q140 Neurons of Huntington’s Disease" @default.
• W4317436732 cites W1496088120 @default.
• W4317436732 cites W1527831788 @default.
• W4317436732 cites W1588358470 @default.
• W4317436732 cites W1591312627 @default.
• W4317436732 cites W1598292644 @default.
• W4317436732 cites W1941550741 @default.
• W4317436732 cites W1974982724 @default.
• W4317436732 cites W1982981376 @default.
• W4317436732 cites W1988004907 @default.
• W4317436732 cites W1995051993 @default.
• W4317436732 cites W2000553921 @default.
• W4317436732 cites W2004098916 @default.
• W4317436732 cites W2012423618 @default.
• W4317436732 cites W2016665157 @default.
• W4317436732 cites W2018254952 @default.
• W4317436732 cites W2030410903 @default.
• W4317436732 cites W2039919932 @default.
• W4317436732 cites W2052970339 @default.
• W4317436732 cites W2053310997 @default.
• W4317436732 cites W2065471902 @default.
• W4317436732 cites W2065770997 @default.
• W4317436732 cites W2068412840 @default.
• W4317436732 cites W2071776514 @default.
• W4317436732 cites W2072363424 @default.
• W4317436732 cites W2073795578 @default.
• W4317436732 cites W2074827827 @default.
• W4317436732 cites W2075140941 @default.
• W4317436732 cites W2082454728 @default.
• W4317436732 cites W2085242832 @default.
• W4317436732 cites W2088310077 @default.
• W4317436732 cites W2094402324 @default.
• W4317436732 cites W2104738142 @default.
• W4317436732 cites W2105149323 @default.
• W4317436732 cites W2109642767 @default.
• W4317436732 cites W2117830068 @default.
• W4317436732 cites W2131091928 @default.
• W4317436732 cites W2146267270 @default.
• W4317436732 cites W2149920094 @default.
• W4317436732 cites W2154727263 @default.
• W4317436732 cites W2158174988 @default.
• W4317436732 cites W2161496026 @default.
• W4317436732 cites W2291779372 @default.
• W4317436732 cites W2335810313 @default.
• W4317436732 cites W2486495263 @default.
• W4317436732 cites W2515584957 @default.
• W4317436732 cites W2516752397 @default.
• W4317436732 cites W2606007772 @default.
• W4317436732 cites W2643595164 @default.
• W4317436732 cites W2752626168 @default.
• W4317436732 cites W2766395183 @default.
• W4317436732 cites W2767573351 @default.
• W4317436732 cites W2782442390 @default.
• W4317436732 cites W2900924817 @default.
• W4317436732 cites W2968521084 @default.
• W4317436732 cites W3001459179 @default.
• W4317436732 cites W3004443958 @default.
• W4317436732 cites W3008587116 @default.
• W4317436732 cites W3016944160 @default.
• W4317436732 cites W3025960839 @default.
• W4317436732 cites W3030261689 @default.
• W4317436732 cites W3049633837 @default.
• W4317436732 cites W3081274437 @default.
• W4317436732 cites W3083169546 @default.
• W4317436732 cites W3089336248 @default.
• W4317436732 cites W3094053673 @default.
• W4317436732 cites W3107550429 @default.
• W4317436732 cites W3110136664 @default.
• W4317436732 cites W3117492839 @default.
• W4317436732 cites W3118434218 @default.
• W4317436732 cites W3129262496 @default.
• W4317436732 cites W3134882742 @default.
• W4317436732 cites W3172617217 @default.
• W4317436732 cites W3189241431 @default.
• W4317436732 cites W3213229139 @default.
• W4317436732 cites W4200286677 @default.
• W4317436732 cites W4283012720 @default.
• W4317436732 cites W4283122590 @default.
• W4317436732 cites W4283729796 @default.
• W4317436732 cites W4297337990 @default.
• W4317436732 cites W4306362132 @default.

• next