Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317438743> ?p ?o ?g. }
- W4317438743 abstract "Abstract Constitutively active mutations in the Gα i2 and Gα oA subunits of heterotrimeric G proteins have been identified in several human cancers including breast cancer, but their functional significance in tumorigenesis and metastasis has not been well characterized. In this study, we show that expression of the constitutively active Gα oA R243H and Gα i2 R179C mutants alone was insufficient to induce mammary tumor formation in mice. However, in transgenic mouse models of breast cancer induced by Neu expression or PTEN loss, we found that the Gα i2 R179C mutant enhanced spontaneous lung metastasis while having no effect on primary tumor initiation and growth. Additionally, we observed that ectopic expression of the Gα oA R243H and Gα i2 R179C mutants in tumor cells promote cell migration in vitro as well as dissemination into multiple organs in vivo by activating c-Src signaling. Thus, our study uncovers a critical function of Gα i/o signaling in accelerating breast cancer metastasis via the c-Src pathway. This work is clinically significant, as it can potentially pave the way to personalized therapies for patients who present with active Gα i/o mutations or elevated Gα i/o signaling by targeting c-Src to inhibit breast cancer metastasis." @default.
- W4317438743 created "2023-01-19" @default.
- W4317438743 creator A5003505208 @default.
- W4317438743 creator A5018422359 @default.
- W4317438743 creator A5024227160 @default.
- W4317438743 creator A5060300614 @default.
- W4317438743 creator A5088871931 @default.
- W4317438743 date "2023-01-19" @default.
- W4317438743 modified "2023-09-23" @default.
- W4317438743 title "Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway" @default.
- W4317438743 cites W1951471355 @default.
- W4317438743 cites W1964186423 @default.
- W4317438743 cites W1974740818 @default.
- W4317438743 cites W1982462460 @default.
- W4317438743 cites W1990401009 @default.
- W4317438743 cites W1990839004 @default.
- W4317438743 cites W1997335773 @default.
- W4317438743 cites W2027372330 @default.
- W4317438743 cites W2044775506 @default.
- W4317438743 cites W2051152907 @default.
- W4317438743 cites W2052370726 @default.
- W4317438743 cites W2053520756 @default.
- W4317438743 cites W2056010202 @default.
- W4317438743 cites W2061134559 @default.
- W4317438743 cites W2064289262 @default.
- W4317438743 cites W2066003961 @default.
- W4317438743 cites W2077517114 @default.
- W4317438743 cites W2103205080 @default.
- W4317438743 cites W2138162490 @default.
- W4317438743 cites W2155490728 @default.
- W4317438743 cites W2280693744 @default.
- W4317438743 cites W2307278282 @default.
- W4317438743 cites W2324860089 @default.
- W4317438743 cites W2809279418 @default.
- W4317438743 cites W2888633597 @default.
- W4317438743 cites W2893413429 @default.
- W4317438743 cites W2948545594 @default.
- W4317438743 cites W2990970256 @default.
- W4317438743 cites W3034094834 @default.
- W4317438743 cites W3084211204 @default.
- W4317438743 cites W3110629517 @default.
- W4317438743 cites W3162543922 @default.
- W4317438743 cites W3192393228 @default.
- W4317438743 cites W4226199002 @default.
- W4317438743 doi "https://doi.org/10.1101/2023.01.16.524334" @default.
- W4317438743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36711612" @default.
- W4317438743 hasPublicationYear "2023" @default.
- W4317438743 type Work @default.
- W4317438743 citedByCount "0" @default.
- W4317438743 crossrefType "posted-content" @default.
- W4317438743 hasAuthorship W4317438743A5003505208 @default.
- W4317438743 hasAuthorship W4317438743A5018422359 @default.
- W4317438743 hasAuthorship W4317438743A5024227160 @default.
- W4317438743 hasAuthorship W4317438743A5060300614 @default.
- W4317438743 hasAuthorship W4317438743A5088871931 @default.
- W4317438743 hasBestOaLocation W43174387431 @default.
- W4317438743 hasConcept C104317684 @default.
- W4317438743 hasConcept C108636557 @default.
- W4317438743 hasConcept C121608353 @default.
- W4317438743 hasConcept C126322002 @default.
- W4317438743 hasConcept C139407321 @default.
- W4317438743 hasConcept C143065580 @default.
- W4317438743 hasConcept C2777609662 @default.
- W4317438743 hasConcept C2779013556 @default.
- W4317438743 hasConcept C2779256057 @default.
- W4317438743 hasConcept C502942594 @default.
- W4317438743 hasConcept C530470458 @default.
- W4317438743 hasConcept C54355233 @default.
- W4317438743 hasConcept C555283112 @default.
- W4317438743 hasConcept C62478195 @default.
- W4317438743 hasConcept C71924100 @default.
- W4317438743 hasConcept C80631254 @default.
- W4317438743 hasConcept C81885089 @default.
- W4317438743 hasConcept C86554907 @default.
- W4317438743 hasConcept C86803240 @default.
- W4317438743 hasConcept C95444343 @default.
- W4317438743 hasConcept C97037327 @default.
- W4317438743 hasConceptScore W4317438743C104317684 @default.
- W4317438743 hasConceptScore W4317438743C108636557 @default.
- W4317438743 hasConceptScore W4317438743C121608353 @default.
- W4317438743 hasConceptScore W4317438743C126322002 @default.
- W4317438743 hasConceptScore W4317438743C139407321 @default.
- W4317438743 hasConceptScore W4317438743C143065580 @default.
- W4317438743 hasConceptScore W4317438743C2777609662 @default.
- W4317438743 hasConceptScore W4317438743C2779013556 @default.
- W4317438743 hasConceptScore W4317438743C2779256057 @default.
- W4317438743 hasConceptScore W4317438743C502942594 @default.
- W4317438743 hasConceptScore W4317438743C530470458 @default.
- W4317438743 hasConceptScore W4317438743C54355233 @default.
- W4317438743 hasConceptScore W4317438743C555283112 @default.
- W4317438743 hasConceptScore W4317438743C62478195 @default.
- W4317438743 hasConceptScore W4317438743C71924100 @default.
- W4317438743 hasConceptScore W4317438743C80631254 @default.
- W4317438743 hasConceptScore W4317438743C81885089 @default.
- W4317438743 hasConceptScore W4317438743C86554907 @default.
- W4317438743 hasConceptScore W4317438743C86803240 @default.
- W4317438743 hasConceptScore W4317438743C95444343 @default.
- W4317438743 hasConceptScore W4317438743C97037327 @default.
- W4317438743 hasLocation W43174387431 @default.
- W4317438743 hasLocation W43174387432 @default.