Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317470387> ?p ?o ?g. }
- W4317470387 endingPage "141510" @default.
- W4317470387 startingPage "141510" @default.
- W4317470387 abstract "Cabazitaxel (CTX) exhibits stronger antineoplastic activity than paclitaxel and docetaxel owing to its capacity to circumvent taxane resistance. However, the therapeutic index of CTX is heavily restricted by poor pharmacokinetics and severe systemic toxicity. Here, a guerbet alcohol, octyldodecanol (OD), was chosen to chemically modify CTX employing tumor-selective sulfur/selenium bonds as linkages, and the prodrugs were capable of forming nanoassemblies spontaneously (termed CTX-S-OD NPs, CTX-Se-OD NPs, CTX-SS-OD NPs, respectively). The CTX-SS-OD NPs displayed superior pharmacokinetic behavior with a 395.5-fold higher AUC than free CTX, allowing for more efficient tumor accumulation. Moreover, the redox sensitive drug release of the prodrug improved the selectivity of cytotoxicity between normal cells and tumor cells, hence reducing the systemic toxicity of prodrug nanoassemblies and facilitating dose intensification. Notably, CTX-SS-OD NPs exhibited potent antitumor efficiency in the 4T1 mouse model due to the elevated tolerance dose. Overall, our studies provided new perspectives for the rational design of prodrug nanoassemblies to deliver high-toxic agents." @default.
- W4317470387 created "2023-01-20" @default.
- W4317470387 creator A5002551693 @default.
- W4317470387 creator A5019330832 @default.
- W4317470387 creator A5020408404 @default.
- W4317470387 creator A5022816109 @default.
- W4317470387 creator A5031121947 @default.
- W4317470387 creator A5040207625 @default.
- W4317470387 creator A5043490236 @default.
- W4317470387 creator A5047810313 @default.
- W4317470387 creator A5064323494 @default.
- W4317470387 creator A5071773009 @default.
- W4317470387 creator A5086013055 @default.
- W4317470387 date "2023-02-01" @default.
- W4317470387 modified "2023-10-16" @default.
- W4317470387 title "Rational design of tumor-selective prodrug nanoassemblies: Greatly improving the in vivo fate and tolerability of high-toxic cabazitaxel" @default.
- W4317470387 cites W1606511994 @default.
- W4317470387 cites W1999627128 @default.
- W4317470387 cites W2028694954 @default.
- W4317470387 cites W2033905916 @default.
- W4317470387 cites W2065704671 @default.
- W4317470387 cites W2070048652 @default.
- W4317470387 cites W2073162583 @default.
- W4317470387 cites W2114282601 @default.
- W4317470387 cites W2136048473 @default.
- W4317470387 cites W2139057757 @default.
- W4317470387 cites W2211284566 @default.
- W4317470387 cites W2261919111 @default.
- W4317470387 cites W2463609338 @default.
- W4317470387 cites W2528255417 @default.
- W4317470387 cites W2747169234 @default.
- W4317470387 cites W2789015323 @default.
- W4317470387 cites W2799378760 @default.
- W4317470387 cites W2801859295 @default.
- W4317470387 cites W2889302258 @default.
- W4317470387 cites W2962843582 @default.
- W4317470387 cites W3043600288 @default.
- W4317470387 cites W3092819831 @default.
- W4317470387 cites W3096705092 @default.
- W4317470387 cites W3120588454 @default.
- W4317470387 cites W3129056703 @default.
- W4317470387 cites W3162155403 @default.
- W4317470387 cites W3184182013 @default.
- W4317470387 cites W3184686389 @default.
- W4317470387 cites W3190896507 @default.
- W4317470387 cites W3200032056 @default.
- W4317470387 cites W4213111444 @default.
- W4317470387 cites W4225243786 @default.
- W4317470387 cites W4226345915 @default.
- W4317470387 cites W4229034336 @default.
- W4317470387 cites W4241416564 @default.
- W4317470387 cites W4295364795 @default.
- W4317470387 doi "https://doi.org/10.1016/j.cej.2023.141510" @default.
- W4317470387 hasPublicationYear "2023" @default.
- W4317470387 type Work @default.
- W4317470387 citedByCount "0" @default.
- W4317470387 crossrefType "journal-article" @default.
- W4317470387 hasAuthorship W4317470387A5002551693 @default.
- W4317470387 hasAuthorship W4317470387A5019330832 @default.
- W4317470387 hasAuthorship W4317470387A5020408404 @default.
- W4317470387 hasAuthorship W4317470387A5022816109 @default.
- W4317470387 hasAuthorship W4317470387A5031121947 @default.
- W4317470387 hasAuthorship W4317470387A5040207625 @default.
- W4317470387 hasAuthorship W4317470387A5043490236 @default.
- W4317470387 hasAuthorship W4317470387A5047810313 @default.
- W4317470387 hasAuthorship W4317470387A5064323494 @default.
- W4317470387 hasAuthorship W4317470387A5071773009 @default.
- W4317470387 hasAuthorship W4317470387A5086013055 @default.
- W4317470387 hasConcept C108215921 @default.
- W4317470387 hasConcept C109316439 @default.
- W4317470387 hasConcept C112705442 @default.
- W4317470387 hasConcept C121608353 @default.
- W4317470387 hasConcept C150903083 @default.
- W4317470387 hasConcept C171250308 @default.
- W4317470387 hasConcept C178790620 @default.
- W4317470387 hasConcept C181389837 @default.
- W4317470387 hasConcept C185592680 @default.
- W4317470387 hasConcept C192562407 @default.
- W4317470387 hasConcept C202751555 @default.
- W4317470387 hasConcept C207001950 @default.
- W4317470387 hasConcept C2776694085 @default.
- W4317470387 hasConcept C2777292972 @default.
- W4317470387 hasConcept C2777511904 @default.
- W4317470387 hasConcept C2777899217 @default.
- W4317470387 hasConcept C2778971682 @default.
- W4317470387 hasConcept C2780192828 @default.
- W4317470387 hasConcept C2781190966 @default.
- W4317470387 hasConcept C29730261 @default.
- W4317470387 hasConcept C530470458 @default.
- W4317470387 hasConcept C53105671 @default.
- W4317470387 hasConcept C54355233 @default.
- W4317470387 hasConcept C55493867 @default.
- W4317470387 hasConcept C86803240 @default.
- W4317470387 hasConcept C98274493 @default.
- W4317470387 hasConceptScore W4317470387C108215921 @default.
- W4317470387 hasConceptScore W4317470387C109316439 @default.
- W4317470387 hasConceptScore W4317470387C112705442 @default.
- W4317470387 hasConceptScore W4317470387C121608353 @default.