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• W4317479917 endingPage "2185" @default.
• W4317479917 startingPage "2171" @default.
• W4317479917 abstract "To develop an efficient MRI pulse sequence to simultaneously measure multiple parameters that have been shown to correlate with tissue nonviability following thermal therapies.A 3D segmented EPI pulse sequence was used to simultaneously measure proton resonance frequency shift (PRFS) MR thermometry (MRT), T1 relaxation time, and shear wave velocity induced by focused ultrasound (FUS) push pulses. Experiments were performed in tissue mimicking gelatin phantoms and ex vivo bovine liver. Using a carefully designed FUS triggering scheme, a heating duty cycle of approximately 65% was achieved by interleaving FUS ablation pulses with FUS push pulses to induce shear waves in the tissue.In phantom studies, temperature increases measured with PRFS MRT and increases in T1 correlated with decreased shear wave velocity, consistent with material softening with increasing temperature. During ablation in ex vivo liver, temperature increase measured with PRFS MRT initially correlated with increasing T1 and decreasing shear wave velocity, and after tissue coagulation with decreasing T1 and increasing shear wave velocity. This is consistent with a previously described hysteresis in T1 versus PRFS curves and increased tissue stiffness with tissue coagulation.An efficient approach for simultaneous and dynamic measurements of PRSF, T1 , and shear wave velocity during treatment is presented. This approach holds promise for providing co-registered dynamic measures of multiple parameters, which correlates to tissue nonviability during and following thermal therapies, such as FUS." @default.
• W4317479917 created "2023-01-20" @default.
• W4317479917 creator A5000968664 @default.
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• W4317479917 creator A5049593207 @default.
• W4317479917 creator A5054001676 @default.
• W4317479917 creator A5066478724 @default.
• W4317479917 date "2023-01-19" @default.
• W4317479917 modified "2023-10-14" @default.
• W4317479917 title "Simultaneous proton resonance frequency <scp>T₁ ‐ MR</scp> shear wave elastography for <scp>MR‐guided focused ultrasound</scp> multiparametric treatment monitoring" @default.
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• W4317479917 doi "https://doi.org/10.1002/mrm.29587" @default.
• W4317479917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36656135" @default.

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