FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317480186> ?p ?o ?g. }

• W4317480186 endingPage "457" @default.
• W4317480186 startingPage "435" @default.
• W4317480186 abstract "Degeneration of the cholinergic basal forebrain is implicated in the development of cognitive deficits and sleep/wake architecture disturbances in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Indirect-acting muscarinic cholinergic receptor agonists, such as acetylcholinesterase inhibitors (AChEIs), remain the only FDA-approved treatments for the cognitive impairments observed in AD that target the cholinergic system. Novel direct-acting muscarinic cholinergic receptor agonists also improve cognitive performance in young and aged preclinical species and are currently under clinical development for AD. However, little is known about the effects of direct-acting muscarinic cholinergic receptor agonists on disruptions of sleep/wake architecture and arousal observed in nonpathologically aged rodents, nonhuman primates, and clinical populations. The purpose of the present study was to provide the first assessment of the effects of the direct-acting M1/M4-preferring muscarinic cholinergic receptor agonist xanomeline on sleep/wake architecture and arousal in young and nonpathologically aged mice, in comparison with the AChEI donepezil, when dosed in either the active or inactive phase of the circadian cycle. Xanomeline produced a robust reversal of both wake fragmentation and disruptions in arousal when dosed in the active phase of nonpathologically aged mice. In contrast, donepezil had no effect on either age-related wake fragmentation or arousal deficits when dosed during the active phase. When dosed in the inactive phase, both xanomeline and donepezil produced increases in wake and arousal and decreases in nonrapid eye movement sleep quality and quantity in nonpathologically aged mice. Collectively, these novel findings suggest that direct-acting muscarinic cholinergic agonists such as xanomeline may provide enhanced wakefulness and arousal in nonpathological aging, MCI, and AD patient populations." @default.
• W4317480186 created "2023-01-20" @default.
• W4317480186 creator A5013200663 @default.
• W4317480186 creator A5028518404 @default.
• W4317480186 creator A5039114499 @default.
• W4317480186 creator A5051209585 @default.
• W4317480186 creator A5062824847 @default.
• W4317480186 date "2023-01-19" @default.
• W4317480186 modified "2023-09-26" @default.
• W4317480186 title "M₁/M₄-Preferring Muscarinic Cholinergic Receptor Agonist Xanomeline Reverses Wake and Arousal Deficits in Nonpathologically Aged Mice" @default.
• W4317480186 cites W12049204 @default.
• W4317480186 cites W133787824 @default.
• W4317480186 cites W1981199626 @default.
• W4317480186 cites W1982064952 @default.
• W4317480186 cites W1983258883 @default.
• W4317480186 cites W1994067502 @default.
• W4317480186 cites W1995170630 @default.
• W4317480186 cites W1997886955 @default.
• W4317480186 cites W2011407865 @default.
• W4317480186 cites W2014349545 @default.
• W4317480186 cites W2015224461 @default.
• W4317480186 cites W2024237085 @default.
• W4317480186 cites W2037063823 @default.
• W4317480186 cites W2037619160 @default.
• W4317480186 cites W2050620515 @default.
• W4317480186 cites W2057679568 @default.
• W4317480186 cites W2067418199 @default.
• W4317480186 cites W2068879317 @default.
• W4317480186 cites W2074092374 @default.
• W4317480186 cites W2074959655 @default.
• W4317480186 cites W2088663330 @default.
• W4317480186 cites W2093374391 @default.
• W4317480186 cites W2095092456 @default.
• W4317480186 cites W2098466209 @default.
• W4317480186 cites W2127841626 @default.
• W4317480186 cites W2135134122 @default.
• W4317480186 cites W2170446709 @default.
• W4317480186 cites W2177243354 @default.
• W4317480186 cites W2213750320 @default.
• W4317480186 cites W2278823400 @default.
• W4317480186 cites W2320251357 @default.
• W4317480186 cites W2320537872 @default.
• W4317480186 cites W2467755953 @default.
• W4317480186 cites W2487848811 @default.
• W4317480186 cites W2520966465 @default.
• W4317480186 cites W2585683277 @default.
• W4317480186 cites W2755489713 @default.
• W4317480186 cites W2766737510 @default.
• W4317480186 cites W2791135672 @default.
• W4317480186 cites W2806853868 @default.
• W4317480186 cites W2890200448 @default.
• W4317480186 cites W2951219679 @default.
• W4317480186 cites W2966973684 @default.
• W4317480186 cites W3015024282 @default.
• W4317480186 cites W3015390054 @default.
• W4317480186 cites W3080951209 @default.
• W4317480186 cites W3082689897 @default.
• W4317480186 cites W3092762255 @default.
• W4317480186 cites W3112948680 @default.
• W4317480186 cites W3116050861 @default.
• W4317480186 cites W3131715422 @default.
• W4317480186 cites W3151084972 @default.
• W4317480186 cites W3214416688 @default.
• W4317480186 cites W4210605243 @default.
• W4317480186 cites W4213447589 @default.
• W4317480186 cites W4220782503 @default.
• W4317480186 cites W4223568662 @default.
• W4317480186 cites W4226359030 @default.
• W4317480186 cites W4292840018 @default.
• W4317480186 doi "https://doi.org/10.1021/acschemneuro.2c00592" @default.
• W4317480186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36655909" @default.
• W4317480186 hasPublicationYear "2023" @default.
• W4317480186 type Work @default.
• W4317480186 citedByCount "1" @default.
• W4317480186 countsByYear W43174801862023 @default.
• W4317480186 crossrefType "journal-article" @default.
• W4317480186 hasAuthorship W4317480186A5013200663 @default.
• W4317480186 hasAuthorship W4317480186A5028518404 @default.
• W4317480186 hasAuthorship W4317480186A5039114499 @default.
• W4317480186 hasAuthorship W4317480186A5051209585 @default.
• W4317480186 hasAuthorship W4317480186A5062824847 @default.
• W4317480186 hasConcept C126322002 @default.
• W4317480186 hasConcept C134018914 @default.
• W4317480186 hasConcept C15744967 @default.
• W4317480186 hasConcept C169760540 @default.
• W4317480186 hasConcept C170493617 @default.
• W4317480186 hasConcept C207723603 @default.
• W4317480186 hasConcept C22885893 @default.
• W4317480186 hasConcept C2776287375 @default.
• W4317480186 hasConcept C2778938600 @default.
• W4317480186 hasConcept C2779134260 @default.
• W4317480186 hasConcept C2779483572 @default.
• W4317480186 hasConcept C2779600325 @default.
• W4317480186 hasConcept C2780904820 @default.
• W4317480186 hasConcept C33789571 @default.
• W4317480186 hasConcept C36951298 @default.
• W4317480186 hasConcept C64123433 @default.
• W4317480186 hasConcept C71924100 @default.

• next