FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4317481328> ?p ?o ?g. }

• W4317481328 abstract "The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen mainly from identifying disease-causing mutations and modeling human bone disease in rodents, in essence, highlighting the integrative nature of skeletal physiology. It has become increasingly clear that bone cells, osteoblasts, osteoclasts, and osteocytes, communicate and regulate the fate of each other through RANK/RANKL/OPG, liver X receptors (LXRs), EphirinB2-EphB4 signaling, sphingolipids, and other membrane-associated proteins, such as semaphorins. Mounting evidence also showed that critical developmental pathways, namely, bone morphogenetic protein (BMP), NOTCH, and WNT, interact each other and play an important role in postnatal bone remodeling. The skeleton communicates not only with closely situated organs, such as bone marrow, muscle, and fat, but also with remote vital organs, such as the kidney, liver, and brain. The metabolic effect of bone-derived osteocalcin highlights a possible role of skeleton in energy homeostasis. Furthermore, studies using genetically modified rodent models disrupting the reciprocal relationship with tropic pituitary hormone and effector hormone have unraveled an independent role of pituitary hormone in skeletal remodeling beyond the role of regulating target endocrine glands. The cytokine-mediated skeletal actions and the evidence of local production of certain pituitary hormones by bone marrow-derived cells displays a unique endocrine-immune-skeletal connection. Here, we discuss recently elucidated mechanisms controlling the remodeling of bone, communication of bone cells with cells of other lineages, crosstalk between bone and vital organs, as well as opportunities for treating diseases of the skeleton." @default.
• W4317481328 created "2023-01-20" @default.
• W4317481328 creator A5001246578 @default.
• W4317481328 creator A5015283872 @default.
• W4317481328 creator A5016253785 @default.
• W4317481328 creator A5018349748 @default.
• W4317481328 creator A5024813161 @default.
• W4317481328 creator A5025782791 @default.
• W4317481328 creator A5028272546 @default.
• W4317481328 creator A5028870447 @default.
• W4317481328 creator A5029736494 @default.
• W4317481328 creator A5035653029 @default.
• W4317481328 creator A5043892922 @default.
• W4317481328 creator A5053710890 @default.
• W4317481328 creator A5062649230 @default.
• W4317481328 creator A5066773921 @default.
• W4317481328 creator A5072635132 @default.
• W4317481328 creator A5080903443 @default.
• W4317481328 creator A5087554418 @default.
• W4317481328 creator A5090570583 @default.
• W4317481328 creator A5090611203 @default.
• W4317481328 date "2023-01-19" @default.
• W4317481328 modified "2023-10-16" @default.
• W4317481328 title "Bone circuitry and interorgan skeletal crosstalk" @default.
• W4317481328 cites W1519258930 @default.
• W4317481328 cites W1594128336 @default.
• W4317481328 cites W1607583153 @default.
• W4317481328 cites W1757602702 @default.
• W4317481328 cites W1838573250 @default.
• W4317481328 cites W1963690512 @default.
• W4317481328 cites W1964439844 @default.
• W4317481328 cites W1967604492 @default.
• W4317481328 cites W1968628080 @default.
• W4317481328 cites W1971124975 @default.
• W4317481328 cites W1972960004 @default.
• W4317481328 cites W1973985023 @default.
• W4317481328 cites W1974470716 @default.
• W4317481328 cites W1975025595 @default.
• W4317481328 cites W1975411570 @default.
• W4317481328 cites W1975587041 @default.
• W4317481328 cites W1976265795 @default.
• W4317481328 cites W1982395713 @default.
• W4317481328 cites W1983434299 @default.
• W4317481328 cites W1984569494 @default.
• W4317481328 cites W1984797903 @default.
• W4317481328 cites W1984821835 @default.
• W4317481328 cites W1987599583 @default.
• W4317481328 cites W1988425215 @default.
• W4317481328 cites W1988807967 @default.
• W4317481328 cites W1989296948 @default.
• W4317481328 cites W1990210398 @default.
• W4317481328 cites W1990357124 @default.
• W4317481328 cites W1992382649 @default.
• W4317481328 cites W1994517874 @default.
• W4317481328 cites W1994960912 @default.
• W4317481328 cites W1997359253 @default.
• W4317481328 cites W1997508587 @default.
• W4317481328 cites W1997880790 @default.
• W4317481328 cites W1998854709 @default.
• W4317481328 cites W1999187583 @default.
• W4317481328 cites W1999826478 @default.
• W4317481328 cites W2000647744 @default.
• W4317481328 cites W2000791145 @default.
• W4317481328 cites W2001903564 @default.
• W4317481328 cites W2002529898 @default.
• W4317481328 cites W2004167485 @default.
• W4317481328 cites W2004269531 @default.
• W4317481328 cites W2005280366 @default.
• W4317481328 cites W2007453290 @default.
• W4317481328 cites W2009880749 @default.
• W4317481328 cites W2009951097 @default.
• W4317481328 cites W2010518541 @default.
• W4317481328 cites W2011188702 @default.
• W4317481328 cites W2013019376 @default.
• W4317481328 cites W2013339414 @default.
• W4317481328 cites W2015050458 @default.
• W4317481328 cites W2016462343 @default.
• W4317481328 cites W2017530514 @default.
• W4317481328 cites W2017975043 @default.
• W4317481328 cites W2019353901 @default.
• W4317481328 cites W2019974313 @default.
• W4317481328 cites W2023826296 @default.
• W4317481328 cites W2024394264 @default.
• W4317481328 cites W2024484448 @default.
• W4317481328 cites W2025059729 @default.
• W4317481328 cites W2026383522 @default.
• W4317481328 cites W2026387061 @default.
• W4317481328 cites W2026726238 @default.
• W4317481328 cites W2029992524 @default.
• W4317481328 cites W2031819996 @default.
• W4317481328 cites W2034356265 @default.
• W4317481328 cites W2035181548 @default.
• W4317481328 cites W2037046278 @default.
• W4317481328 cites W2037262941 @default.
• W4317481328 cites W2037412043 @default.
• W4317481328 cites W2038607522 @default.
• W4317481328 cites W2039839227 @default.
• W4317481328 cites W2044703599 @default.
• W4317481328 cites W2046051881 @default.
• W4317481328 cites W2047761422 @default.

• next