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- W4317490004 endingPage "111843" @default.
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- W4317490004 abstract "A pH-sensitive, methoxy(polyethylene glycol)(hydrazone)block(hydroxypropyl methacrylamide), covalently linked to gemcitabine (mP(Hz)-bH(GEM)), was developed, which formed spherical nanoaggregates in the aqueous environment. The conjugate/nanoaggregates (NA) were physicochemically characterized using DLS, 1H NMR, FTIR, GPC, SAXS, MALDI-TOF, pH-dependent drug release, and hemolysis studies. Human HR+/- cells, MCF-7 and MDA-MB-231 were used to investigate the NA's therapeutic effectiveness in vitro via cytotoxicity, DNA fragmentation, cellular uptake, cell cycle assays, nuclear staining, and immunoblot analysis. mP(Hz)-bH(GEM) NAs exhibited decreased IC50 towards MCF-7 and MDA-MB-231 than free GEM. mP(Hz)-bH(GEM) NAs caused extensive DNA damage, cell-growth arrest (G1/S), increased intrinsic apoptotic markers, caspase 3, 7, p53, cytochrome-C, and suppressed the proliferative marker Bcl-2. Therefore, this new mP(Hz)-bH(GEM) nanoaggregate formulation could be an alternative, safe, biocompatible, and effective treatment option for breast cancer therapy." @default.
- W4317490004 created "2023-01-20" @default.
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- W4317490004 date "2023-03-01" @default.
- W4317490004 modified "2023-10-17" @default.
- W4317490004 title "Block HPMA-based pH-sensitive gemcitabine pro-drug nanoaggregates for cancer treatment" @default.
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- W4317490004 doi "https://doi.org/10.1016/j.eurpolymj.2023.111843" @default.
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